CD172a (SIRPα) antibodies, rat

CD172a (SIRPα) antibodies, rat

Clone: REA490 | Dilution: 1:10
Clone REA490 recognizes the rat antigen CD172a, a 75–110 kDa glycosylated receptor-like protein, which is also known as SIRPα or SHPS-1. It binds to its ligand CD47, which inhibits cytokine production by mature dendritic cells (DCs) and avoids maturation of immature DCs. SHPS-1 plays a role in the negative regulation of receptor tyrosine kinase–coupled cellular responses induced by cell adhesion, growth factors, or insulin and mediates negative regulation of phagocytosis, mast cell, and DC activation. CD172a is expressed by neurons and myeloid cells, such as monocytes, macrophages, granulocytes, and DCs.
Additional information: Clone REA490 displays negligible binding to Fc receptors.

Alternative names

Sirp, Bit, Ptpns1, Shps1, Mfr, SIRPα

Technical specifications

  • Antigen: CD172a (SIRPα)
  • Clone: REA490
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Sirp, Bit, Ptpns1, Shps1, Mfr, SIRPα
  • Entrez Gene ID: 25528
  • Molecular mass of antigen [kDa]: 53
  • Distribution of antigen: dendritic cells, mast cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, Biotin
  • Selected references

    1. Fujioka, Y. et al. (1996) A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. Mol. Cell. Biol. 16(12): 6887-6899
    2. Takada, T. et al. (1998) Roles of the complex formation of SHPS-1 with SHP-2 in insulin-stimulated mitogen-activated protein kinase activation. J. Biol. Chem. 273(15): 9234-9242
    3. Adams, S. et al. (1998) Signal-regulatory protein is selectively expressed by myeloid and neuronal cells. J. Immunol. 161: 1853-1859
Product options: 8
9 µg in 300 µL (1)
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30 µg in 1 mL (1)
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9 µg in 300 µL (1)
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30 µg in 1 mL (1)
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9 µg in 300 µL (1)
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30 µg in 1 mL (1)
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9 µg in 300 µL (1)
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30 µg in 1 mL (1)
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