CD171 (L1CAM) antibodies, human

CD171 (L1CAM) antibodies, human

Clone: REA163 | Dilution: 1:11
Clone REA163 recognizes human CD171, a single-pass type I membrane glycoprotein belonging to the immunoglobulin superfamily. Also known as L1 cell adhesion molecule (L1CAM) or NCAM-L1, CD171 belongs to a subgroup of cell adhesion molecules, which consist of six Ig-like domains, five fibronectin type III (FNIII)-like domains, a transmembrane region, and a cytoplasmic domain. Expression of CD171 is found on tetanus-toxin positive neurons, endothelial cells, certain epithelial cells, reticular fibroblasts, and several malignant tumors including colon and breast carcinomas, colon melanoma, tumor cells of neuronal, and mesothelial origin, where a role of CD171 in augmenting tumor growth has been demonstrated. Thus, CD171 is considered a novel marker for carcinoma progression. CD171 displays binding to a number of ligands including homophilic interaction with itself and heterophilic binding to integrins, other cell adhesion molecules, extracellular matrix molecules. It is involved in the development of the nervous system and regulates processes such as neuron–neuron adhesion, myelination, axonal guidance, and neuronal migration.
Additional information: Clone REA163 displays negligible binding to Fc receptors.

Alternative names

L1CAM, CAML1, HSAS, MASA, MIC5, N-CAM-L1, S10, SPG1

Technical specifications

  • Antigen: CD171 (L1CAM)
  • Clone: REA163
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: L1CAM, CAML1, HSAS, MASA, MIC5, N-CAM-L1, S10, SPG1
  • Distribution of antigen: neurons, endothelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin
  • Selected references

    1. Rathjen, F. G. et al. (1984) Immunocytological and biochemical characterization of a new neuronal cell surface component (L1 antigen) which is involved in cell adhesion. EMBO J. 3(1): 1-10
    2. Schaefer, A. W. et al. (1999) Activation of the MAPK signal cascade by the neural cell adhesion molecule L1 requires L1 internalization. J. Biol. Chem. 274: 37965-37973
    3. Needham, L. K. et al. (2001) Cytoplasmic domain mutations of the L1 cell adhesion molecule reduce L1-ankyrin interactions. J. Neurosci. 21: 1490-1500
    4. Huszar, M. et al. (2006) Expression profile analysis in multiple human tumors identifies L1 (CD171) as a molecular marker for differential diagnosis and targeted therapy. Hum. Pathol. 37(8): 1000-1008
Product options: 8
130-100-692

CD171 (L1CAM)-PE, human

for 30
tests
(1)
-
130-100-691

CD171 (L1CAM)-PE, human

for 100
tests
(1)
-
130-100-686

CD171 (L1CAM)-APC, human

for 30
tests
(1)
-
130-100-684

CD171 (L1CAM)-APC, human

for 100
tests
(1)
-
130-100-701

CD171 (L1CAM)-PE-Vio770, human

for 30
tests
(1)
-
130-100-700

CD171 (L1CAM)-PE-Vio770, human

for 100
tests
(1)
-
130-100-703

CD171 (L1CAM)-Biotin, human

for 30
tests
(1)
-
130-100-702

CD171 (L1CAM)-Biotin, human

for 100
tests
(1)
-