CD166 antibodies, mouse

CD166 antibodies, mouse

Clone: REA370 | Dilution: 1:10
Clone REA370 recognizes the mouse CD166 antigen, a Single-pass type I membrane protein also known as Activated leukocyte cell adhesion molecule (ALCAM). CD166 is a member of the immunoglobulin gene superfamily which is expressed by activated leukocytes and thymic epithelial cells and is a ligand for the lymphocyte antigen CD6. It is also expressed at high levels in the brain and lung, at lower levels in the liver and the kidney, and on a number of cell lines. CD166 expression is pathologically correlated with aggressive disease in a variety of cancers including melanoma, prostate, breast, ovarian, esophageal, and bladder cancers. It is also a universal functional marker of murine and human hematopoietic stem cells (HSC) and osteoblasts within the hematopoietic niche and it is involved in modulating HSC-niche interactions and HSC fate.
Additional information: Clone REA370 displays negligible binding to Fc receptors.

Alternative Names

ALCAM, BEN, DM-GRASP, MuSC, SC1

Technical specifications

  • Antigen: CD166
  • Clone: REA370
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: ALCAM, BEN, DM-GRASP, MuSC, SC1
  • Entrez Gene ID: 11658
  • Molecular mass of antigen [kDa]: 62
  • Distribution of antigen: leukocytes, thymic epithelial cells, brain, lung, liver, kidney, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
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