CD162 antibodies, human

CD162 antibodies, human

Clone: REA319 | Dilution: 1:11
Clone REA319 recognizes the human CD162 antigen, a single-pass type I membrane protein which is also known as P-selectin glycoprotein ligand 1 (PSGL-1). CD162 is expressed on neutrophils, monocytes, and most lymphocytes. It is the high affinity receptor for CD62P (P-selectin) on myeloid cells and stimulated T lymphocytes and mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. CD162 is also involved in homeostasis including stem cell homing to the thymus and mature T cell homing to secondary lymphoid organs. It has been found to bind the homeostatic chemokines CCL19 and CCL21 and to support the chemotactic response to these chemokines.
Additional information: Clone REA319 displays negligible binding to Fc receptors.

Alternative names

PSGL-1, SELPLG

Technical specifications

  • Antigen: CD162
  • Clone: REA319
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: PSGL-1, SELPLG
  • Entrez Gene ID: 9332
  • Molecular mass of antigen [kDa]: 121
  • Distribution of antigen: neutrophils, monocytes, lymphocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Frenette, P. S. et al. (2000)
      P-selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions
      in vivo
      .
      J. Exp. Med. 191(8): 1413-1422
    2. Sako, D. et al. (1993) Expression cloning of a functional glycoprotein ligand for P-selectin. Cell 75(6): 1179-1186
    3. Carlow, D. A. et al. (2009) PSGL-1 function in immunity and steady state homeostasis. Immunol. Rev. 230(1): 75-96
    4. Evani, S.J. et al. (2016)
      Biophysical regulation of
      Chlamydia pneumoniae
      -infected monocyte recruitment to atherosclerotic foci.
      Sci. Rep. 6
Product options: 12
130-104-753

CD162-FITC, human

for 30
tests
(1)
-
130-104-706

CD162-FITC, human

for 100
tests
(1)
-
130-104-754

CD162-PE, human

for 30
tests
(1)
-
130-104-707

CD162-PE, human

for 100
tests
(1)
-
130-104-755

CD162-APC, human

for 30
tests
(1)
-
130-104-708

CD162-APC, human

for 100
tests
(1)
-
130-104-756

CD162-PE-Vio770, human

for 30
tests
(1)
-
130-104-709

CD162-PE-Vio770, human

for 100
tests
(1)
-
130-104-757

CD162-APC-Vio770, human

for 30
tests
(1)
-
130-104-710

CD162-APC-Vio770, human

for 100
tests
(1)
-
130-104-752

CD162-Biotin, human

for 30
tests
(1)
-
130-104-705

CD162-Biotin, human

for 100
tests
(1)
-