CD161 antibodies, human

CD161 antibodies, human

Clone: REA631 | Dilution: 1:50
Clone REA631 recognizes the human CD161 antigen, a 80 kDa single-pass type II membrane protein, which is also known as natural killer cell surface protein P1A (NKR-P1A) or C-type lectin domain family 5 member B (CLEC5B). CD161 is expressed on most NK cells and subsets of T cells. In peripheral blood, CD161 is preferentially expressed on T cells of memory phenotype, but it can also be found on subsets of thymocytes and fetal liver T cells. CD161 has been implicated in triggering NK-mediated cytotoxicity, contributing to target cell recognition by NK cells.
Additional information: Clone REA631 displays negligible binding to Fc receptors.

Alternative names

NKR-P1A, HNKR-P1a, CLEC5B

Technical specifications

  • Antigen: CD161
  • Clone: REA631
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: NKR-P1A, HNKR-P1a, CLEC5B
  • Entrez Gene ID: 3820
  • Molecular mass of antigen [kDa]: 25
  • Distribution of antigen: liver, NK cells, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, Biotin
  • Selected references

    1. Lanier, L. L. et al. (1994) Human NKR-P1A. A disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes. J. Immunol. 153: 2417-2428
    2. Pozo, D. et al. (2006) CD161 (human NKRP1A) signaling in NK cells involves the activation of acid sphingomyelinase. J. Immunol. 176: 2397-2406
    3. Takahashi, T. et al. (2006) Expression of CD161 (NKR-P1A) defines subsets of human CD4 and CD8 T cells with different functional activities.​ J. Immunol. 176: 211-216
Product options: 10
130-114-124

CD161-VioBright FITC, human

for 30
tests
(1)
-
130-113-598

CD161-VioBright FITC, human

for 100
tests
(1)
-
130-114-122

CD161-PE, human

for 30
tests
(1)
-
130-113-596

CD161-PE, human

for 100
tests
(1)
-
130-114-121

CD161-APC, human

for 30
tests
(1)
-
130-113-595

CD161-APC, human

for 100
tests
(1)
-
130-114-123

CD161-PE-Vio770, human

for 30
tests
(1)
-
130-113-597

CD161-PE-Vio770, human

for 100
tests
(1)
-
130-119-711

CD161-Biotin, human

for 30
tests
(1)
-
130-119-621

CD161-Biotin, human

for 100
tests
(1)
-