CD159c (NKG2C) antibodies, human

CD159c (NKG2C) antibodies, human

Clone: REA205 | Dilution: 1:50
Clone REA205 recognizes the CD159c antigen, a calcium-dependent (C-type) lectin, which is also known as NKG2C type II integral membrane protein or KLRC2. CD159c heterodimerizes with CD94 to form a complex that recognizes HLA-E as ligand. Clone REA205 detects the human CD159c/CD94 heterodimer and does not cross-react with the human CD159a/CD94 heterodimer or with the human CD94 homodimer. CD159c is expressed primarily on natural killer (NK) cells and receptor ligation results in NK cell activation. The proportion of CD3
T cells expressing the CD159c/CD94 complex is elevated under pathologic conditions, such as human CMV infection, active celiac disease, paroxysmal nocturnal hemoglobinuria, Stevens-Johnson syndrome, and toxic epidermal necrolysis. Moreover, CD159c can mediate the expansion of infiltrating cytotoxic CD8
T cells in active celiac patients.
Additional information: Clone REA205 displays negligible binding to Fc receptors.

Alternative Names

KLRC2, CD159c, NKG2-C, NKG2C
REAfinity clone is tested against different known clones, in a blocking experiment, to identify whether they recognize completely overlapping (++), partially overlapping (+), or completely different epitopes (-). In a blocking experiment, cells are incubated with an excess of purified unconjugated REAfinity clone followed by staining with conjugated form of the different hybridoma clones. 
Other clonesOverlap in epitope recognition with REA205

Technical specifications

  • Antigen: CD159c (NKG2C)
  • Clone: REA205
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: KLRC2, CD159c, NKG2-C, NKG2C
  • Entrez Gene ID: 3822
  • Molecular mass of antigen [kDa]: 26
  • Distribution of antigen: NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, APC
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