CD158b (KIR2DL2/DL3) antibodies, human

CD158b (KIR2DL2/DL3) antibodies, human

Clone: REA1006 | Dilution: 1:50
Clone REA1006 recognizes the human CD158b1 (KIR2DL2), CD158b2 (KIR2DL3), and CD158j (KIR2DS2) antigens, members of the killer immunoglobulin-like receptor (KIR) family expressed on natural killer (NK) cells and subsets of T cells.
KIRs contribute to the regulation of NK cell–mediated cytotoxicity and possess high allelic polymorphism with either 2 or 3 Ig-like extracellular domains. According to the length of their cytoplasmic tail, KIRs can be further subdivided in inhibitory KIRs (KIR2DL or KIR3DL) and activating KIRs (KIR2DS or KIR3DS). CD158b provides an inhibitory signal on NK cell lytic activity upon interaction with HLA C (e.g. alleles HLA-Cw1, HLA-Cw3, HLA-Cw7) in an antigen-independent manner.
Additional information: Clone REA1006 displays negligible binding to Fc receptors.

Alternative Names

KIR2DL2, KIR2DL3

Technical specifications

  • Antigen: CD158b (KIR2DL2/DL3)
  • Clone: REA1006
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: KIR2DL2, KIR2DL3
  • Entrez Gene ID: 3803, 3804
  • Molecular mass of antigen [kDa]: 36
  • Distribution of antigen: NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, PE-Vio615, PE-Vio770, APC-Vio770, VioBright 515

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