CD158a (KIR2DL1) antibodies, human

CD158a (KIR2DL1) antibodies, human

Clone: REA284 | Dilution: 1:11
Clone REA284 recognizes human CD158a (KIR2DL1), but not KIR2DL2, 2DL3, 2DL4, 2DL5, 2DS1, 2DS2, 2DS4, 3DL1, 3DL2, or 3DS1. CD158a is 58 kDa protein, also known as KIR2DL1. CD158a is a member of the family of killer cell immunoglobulin-like receptors (KIRs) comprising transmembrane glycoproteins expressed on NK cells and a subset of T cells. Many groups of KIRs exist including KIR3DL1-3, KIR3DS1, KIR2DL1-5, and KIR2DS1-5. The isoforms have either a short (S) or long (L) cytoplasmic domain which transduce either an activating or inhibitory signal, respectively. The ligands of CD158a (KIR2DL1) are HLA-C molecules with Asn77 and Lys80, but not Ser77 and Asn80.
Additional information: Clone REA284 displays negligible binding to Fc receptors.

Alternative Names

KIR2DL1, KIR-K64, KIR221, NKAT, NKAT-1, p58.1

Technical specifications

  • Antigen: CD158a (KIR2DL1)
  • Clone: REA284
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: KIR2DL1, KIR-K64, KIR221, NKAT, NKAT-1, p58.1
  • Entrez Gene ID: 3802
  • Molecular mass of antigen [kDa]: 36
  • Distribution of antigen: NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
REAfinity clone is tested against different known clones, in a blocking experiment, to identify whether they recognize completely overlapping (++), partially overlapping (+), or completely different epitopes (-). In a blocking experiment, cells are incubated with an excess of purified unconjugated REAfinity clone followed by staining with conjugated form of the other known clones. 
Other clonesOverlap in epitope recognition with REA284

Related products

3 products available
Product options: -

Product information

Order no.