CD152 antibodies, mouse

CD152 antibodies, mouse

Clone: REA984 | Dilution: 1:50
Clone REA984 recognizes the mouse CD152 antigen, also known as cytotoxic T lymphocyte antigen-4 (CTLA-4), which is a 33 kDa member of the immunoglobin superfamily and is expressed on activated T cells at a low level. CTLA-4 and CD28 have similarities concerning B7 family counter-receptors. While CD28 delivers a co-stimulary signal in T cell activation, CD152 restricts the progression of T cells to an activated state by inhibiting interleukin 2 (IL-2) secretion and cellular proliferation. A large proportion of CTLA-4 is intracellular localized. For a complete detection it may be necessary to assess intracellular staining in addition to surface expression of CD152.
Additional information: Clone REA984 displays negligible binding to Fc receptors.

Alternative Names

CTLA-4, CTLA4, Ly-56

Technical specifications

  • Antigen: CD152
  • Clone: REA984
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: CTLA-4, CTLA4, Ly-56
  • Entrez Gene ID: 12477
  • Molecular mass of antigen [kDa]: 21
  • Distribution of antigen: B cells, lymphocytes, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, Biotin

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