CD146 (LSEC) antibodies, mouse

CD146 (LSEC) antibodies, mouse

Clone: ME-9F1 | Dilution: 1:10
The CD146 (LSEC) antibody (clone ME-9F1) binds to the CD146 antigen, which is expressed on mouse endothelial cells, including liver sinusoidal endothelial cells (LSECs), smooth muscle cells, and the basal membrane.
LSECs are microvascular endothelial cells lining the hepatic sinusoidal wall. Their strategic positioning favors a tight interaction with lymphocytes migrating through the liver. They possess a high capacity for antigen uptake and processing. However, in contrast to professional antigen-presenting cells (e.g. dendritic cells), they express only low levels of costimulatory molecules.

Alternative Names

MCAM, 1-gicerin, CD149, MUC18, S-endo, s-gicerin, Endo-CAM, Mel-CAM

Technical specifications

  • Antigen: CD146 (LSEC)
  • Clone: ME-9F1
  • Isotype: rat IgG2aκ
  • Isotype control: Rat IgG2a – isotype control antibodies
  • Alternative names of antigen: MCAM, 1-gicerin, CD149, MUC18, S-endo, s-gicerin, Endo-CAM, Mel-CAM
  • Entrez Gene ID: 84004
  • Molecular mass of antigen [kDa]: 69
  • Distribution of antigen: bone marrow, dendritic cells, endothelial cells, epithelial cells, fibroblasts, mesenchymal stem cells, ES and iPS cells, smooth muscle, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PerCP-Vio700, Biotin
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