CD141 (BDCA-3) antibodies, mouse

CD141 (BDCA-3) antibodies, mouse

Clone: REA964 | Dilution: 1:50
Clone REA964 recognizes the mouse CD141 antigen, which is also known as BDCA-3, thrombomodulin, or fetomodulin. CD141 is a type I cell surface glycoprotein expressed mainly on endothelial cells. CD141 functions as a specific endothelial cell receptor for thrombin. This complex cleaves protein C and the thrombin activatable fibrinolysis Inhibitor (TAFI), initiating an anticoagulant pathway.
Additional information: Clone REA964 displays negligible binding to Fc receptors.

Alternative Names

Thrombomodulin, Fetomodulin, TM, BDCA-3

Technical specifications

  • Antigen: CD141 (BDCA-3)
  • Clone: REA964
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Thrombomodulin, Fetomodulin, TM, BDCA-3
  • Entrez Gene ID: 21824
  • Molecular mass of antigen [kDa]: 60
  • Distribution of antigen: endothelial cells, macrophages, monocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio770, APC-Vio770, Biotin
  • Selected References

    1. Dittman, W. A. et al. (1988) The structure and function of mouse thrombomodulin. Phorbol myristate acetate stimulates degradation and synthesis of thrombomodulin without affecting mRNA levels in hemangioma cells. J. Biol. Chem. 263(30): 15815-15822
    2. Bajzar, L. et al. (1996) TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex. J. Biol. Chem. 271(28): 16603-16608
    3. Isermann, B. et al. (2001) Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosis. J. Clin. Invest. 108(4): 537-546

Related products

1 products available
Product options: 10
130-116-094

CD141 (BDCA-3)-PE, mouse

30 µg in 200 µL (1)
-
130-116-019

CD141 (BDCA-3)-PE, mouse

150 µg in 1 mL (1)
-
130-116-095

CD141 (BDCA-3)-APC, mouse

30 µg in 200 µL (1)
-
130-116-020

CD141 (BDCA-3)-APC, mouse

150 µg in 1 mL (1)
-
130-116-099

CD141 (BDCA-3)-VioBlue, mouse

30 µg in 200 µL (1)
-
130-116-096

CD141 (BDCA-3)-PE-Vio770, mouse

30 µg in 200 µL (1)
-
130-116-021

CD141 (BDCA-3)-PE-Vio770, mouse

150 µg in 1 mL (1)
-
130-116-097

CD141 (BDCA-3)-APC-Vio770, mouse

30 µg in 200 µL (1)
-
130-116-092

CD141 (BDCA-3)-Biotin, mouse

30 µg in 200 µL (1)
-
130-116-017

CD141 (BDCA-3)-Biotin, mouse

150 µg in 1 mL (1)
-