CD141 (BDCA-3) antibodies, human

CD141 (BDCA-3) antibodies, human

Clone: REA674 | Dilution: 1:11
Clone REA674 recognizes the human CD141 (BDCA-3) antigen, which is expressed at high levels on a minor subpopulation of human myeloid dendritic cells (about 0.02% of blood leukocytes). CD141 (BDCA-3)
high
blood dendritic cells are CD11c
dim
, CD123
, CD4
+
, Lin
, CD45RO
+
, CD2
, and CD16
. They express myeloid lineage markers, such as CD13 and CD33, and have a monocytoid morphology. Unlike CD1c (BDCA-1)
+
blood dendritic cells, CD141 (BDCA-3)
high
blood dendritic cells lack expression of CD2 and Fc receptors such as CD32, CD64, or FcεRI. CD141 (BDCA-3) is also present at very low levels on CD14
+
monocytes, granulocytes, CD303 (BDCA‑2)
+
CD304 (BDCA-4/Neuropilin-1)
+
plasmacytoid, and CD1c (BDCA-1)
+
myeloid dendritic cells. CD141 (BDCA-3)
high
CD1c (BDCA-1)
myeloid dendritic cells have been designated type-2 myeloid dendritic cells (MDC2s). CD141 is also known as thrombomodulin; thrombomodulin mediates co-agglutination by interaction with thrombin and protein C, though nothing is known about its function on MDC2s.
Additional information: Clone REA674 displays negligible binding to Fc receptors.

Alternative Names

Thrombomodulin, Fetomodulin, TM

Technical specifications

  • Antigen: CD141 (BDCA-3)
  • Clone: REA674
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Thrombomodulin, Fetomodulin, TM
  • Entrez Gene ID: 7056
  • Molecular mass of antigen [kDa]: 59
  • Distribution of antigen: dendritic cells, monocytes, granulocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, VioBlue, PE-Vio770, APC-Vio770, PerCP-Vio700, VioBright 515, Biotin
Product options: 16

Product information

Size
Order no.
Price

CD141 (BDCA-3)-FITC, human

  • REA674
  • 1:11
  • For research use only
for 30
tests
(1)
130-110-358
-

CD141 (BDCA-3)-FITC, human

  • REA674
  • 1:11
  • For research use only
for 100
tests
(1)
130-110-257
-

CD141 (BDCA-3)-PE, human

  • REA674
  • 1:11
  • For research use only
for 30
tests
(1)
130-110-359
-

CD141 (BDCA-3)-PE, human

  • REA674
  • 1:11
  • For research use only
for 100
tests
(1)
130-110-258
-

CD141 (BDCA-3)-VioBlue, human

  • REA674
  • 1:11
  • For research use only
for 30
tests
(1)
130-111-045
-

CD141 (BDCA-3)-VioBlue, human

  • REA674
  • 1:11
  • For research use only
for 100
tests
(1)
130-110-928
-

CD141 (BDCA-3)-PE-Vio770, human

  • REA674
  • 1:11
  • For research use only
for 30
tests
(1)
130-110-361
-

CD141 (BDCA-3)-PE-Vio770, human

  • REA674
  • 1:11
  • For research use only
for 100
tests
(1)
130-110-260
-

CD141 (BDCA-3)-APC-Vio770, human

  • REA674
  • 1:11
  • For research use only
for 30
tests
(1)
130-110-362
-

CD141 (BDCA-3)-APC-Vio770, human

  • REA674
  • 1:11
  • For research use only
for 100
tests
(1)
130-110-261
-

CD141 (BDCA-3)-PerCP-Vio700, human

  • REA674
  • 1:11
  • For research use only
for 30
tests
(1)
130-110-363
-

CD141 (BDCA-3)-PerCP-Vio700, human

  • REA674
  • 1:11
  • For research use only
for 100
tests
(1)
130-110-262
-

CD141 (BDCA-3)-VioBright 515, human

  • REA674
  • 1:11
  • For research use only
for 30
tests
(1)
130-110-364
-

CD141 (BDCA-3)-VioBright 515, human

  • REA674
  • 1:11
  • For research use only
for 100
tests
(1)
130-110-263
-

CD141 (BDCA-3)-Biotin, human

  • REA674
  • 1:11
  • For research use only
for 30
tests
(1)
130-110-357
-

CD141 (BDCA-3)-Biotin, human

  • REA674
  • 1:11
  • For research use only
for 100
tests
(1)
130-110-256
-

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