CD141 (BDCA-3) antibodies, human

CD141 (BDCA-3) antibodies, human

Clone: AD5-14H12
Clone AD5-14H12 recognizes the human CD141 (BDCA-3) antigen which is expressed at high levels on a minor subpopulation of human myeloid dendritic cells (about 0.02% of blood leukocytes). CD141 (BDCA‑3)
high
blood dendritic cells are CD11c
dim
, CD123
, CD4
+
, Lin
, CD45RO
+
, CD2
, and CD16
. They express myeloid lineage markers, such as CD13 and CD33, and have a monocytoid morphology. Unlike CD1c (BDCA-1)
+
blood dendritic cells, CD141 (BDCA-3)
high
blood dendritic cells lack expression of CD2 and Fc receptors such as CD32, CD64, or FcεRI. CD141 (BDCA-3) is also present at very low levels on CD14
+
monocytes, granulocytes, CD303 (BDCA‑2)
+
CD304 (BDCA-4/Neuropilin-1)
+
plasmacytoid and CD1c (BDCA-1)
+
myeloid dendritic cells. CD141 (BDCA‑3)
high
CD1c (BDCA-1)
myeloid dendritic cells have been designated type-2 myeloid dendritic cells (MDC2s). CD141 is also known as thrombomodulin; thrombomodulin mediates co-agglutination by interaction with thrombin and protein C, though nothing is known about its function on MDC2s.

Alternative Names

THBD, AHUS6, BDCA3, THPH12, THRM, TM

Technical specifications

  • Antigen: CD141 (BDCA-3)
  • Clone: AD5-14H12
  • Isotype: mouse IgG1
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: THBD, AHUS6, BDCA3, THPH12, THRM, TM
  • Entrez Gene ID: 7056
  • Molecular mass of antigen [kDa]: 59
  • Distribution of antigen: endothelial cells, megakaryocytes, monocytes, myeloid cells, neutrophils, platelets, smooth muscle
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
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