CD14 antibodies, human

CD14 antibodies, human

Clone: TÜK4 | Dilution: 1:11
Clone TÜK4 recognizes the human CD14 antigen and cross-reacts with non-human primate CD14. The CD14 antigen is a high affinity receptor for lipopolysaccharides (LPS) and LPS–binding protein (LBP)–complexes. It is part of the functional heteromeric LPS receptor complex comprised of CD14, TLR4, and MD-2.
CD14 is strongly expressed on most human monocytes and macrophages in peripheral blood, other body fluids, and various tissues, such as lymph nodes and spleen. CD14 is expressed at high levels, also on a few CD1c (BDCA-1)
+
CD2
+
myeloid dendritic cells and at low levels on neutrophilic granulocytes.
Ex vivo
differentiation of monocytes to dendritic cells is associated with down–regulation of CD14 antigen expression.

Alternative Names

LPS R

Technical specifications

  • Antigen: CD14
  • Clone: TÜK4
  • Isotype: mouse IgG2aκ
  • Isotype control: Mouse IgG2a – isotype control antibodies
  • Alternative names of antigen: LPS R
  • Entrez Gene ID: 929
  • Molecular mass of antigen [kDa]: 37
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    pigtail monkey (
    Macaca nemestrina
    )
    ,
    cotton-top tamarin (
    Saguinus oedipus
    )
    , pig, cow, sheep, goat, dog, mink, rabbit
  • Distribution of antigen: B cells, dendritic cells, epithelial cells, granulocytes, Langerhans cells, liver, macrophages, monocytes, osteoclasts, plasma cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, VioBlue, PE-Vio615, PE-Vio770, APC-Vio770, Biotin
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