CD135 (FLT3) antibodies, human

CD135 (FLT3) antibodies, human

Clone: REA786 | Dilution: 1:50
Clone REA786 recognizes the human CD135 antigen, a single-pass type I membrane protein also known as Fms-like tyrosine kinase receptor 3 (FLT3) or fetal liver kinase-2 (FLK-2). CD135 belongs to the same family as FMS, KIT, and the two genes encoding PDGFRα and β. CD135 is normally expressed by hematopoietic stem and progenitor cells and expression is lost as hematopoietic cells differentiate. Although, CD135 expression is usually lost upon hematopoietic stem cell (HSC) differentiation, dendritic cells are an exception, as mature dendritic cells (DCs) display persistent FLT3 expression. CD135 is also expressed on malignant hematopoietic cells including AML, ALL, and CML-BC. All hematopoietic cells develop from CD135 negative hematopoietic stem cells through CD135 positive progenitor cells. In synergy with other growth factors like G-CSF, GM-CSF, SCF, and IL-3, ligation of CD135 with FLT3 ligand promotes the differentiation, proliferation, and survival of hematopoietic progenitor cells and of dendritic cells. As a result early B cell lineage differentiation as well as expansion of monocytes and immature dendritic cells are stimulated.
Additional information: Clone REA786 displays negligible binding to Fc receptors.

Alternative Names

FLT3, FLK-2, STK-1

Technical specifications

  • Antigen: CD135 (FLT3)
  • Clone: REA786
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: FLT3, FLK-2, STK-1
  • Entrez Gene ID: 2322
  • Molecular mass of antigen [kDa]: 110
  • Distribution of antigen: hematopoietic stem cells, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, VioBright 515, Biotin
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