CD134 (OX40) antibodies, rat

CD134 (OX40) antibodies, rat

Clone: REA540 | Dilution: 1:10
Clone REA540 recognizes the rat CD134 (OX40) antigen, a 50 kDa glycoprotein which is a member of the TNFR superfamily. It contains a typical signal sequence and a single putative transmembrane sequence of 25 predominantly hydrophobic amino acids giving an extracellular domain of 191 amino acids and a cytoplasmic domain of 36 amino acids. The expression of CD134 is restricted to activated rat CD4
+
T cells and is up-regulated within hours after activation. CD134 and its ligand CD252 (CD134L, OX40L), which is expressed on activated T and B lymphocytes and also a member of the tumor necrosis factor receptor superfamily, were suggested to mediate the interaction between T cells and B cells.
Additional information: Clone REA540 displays negligible binding to Fc receptors.

Alternative Names

TNFRSF4, OX-40, Txgp1, MRC OX40

Technical specifications

  • Antigen: CD134 (OX40)
  • Clone: REA540
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: TNFRSF4, OX-40, Txgp1, MRC OX40
  • Entrez Gene ID: 25572
  • Molecular mass of antigen [kDa]: 28
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin
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