CD123 antibodies, mouse

CD123 antibodies, mouse

Clone: REA114 | Dilution: 1:10
Clone REA114 recognizes CD123, the alpha chain of the IL-3 receptor. CD123 is 60–70 kDa membrane glycoprotein and interacts in mice with common beta chain (betac) and beta IL-3 subunits to form functional heterodimeric IL-3 receptors. CD123 alone can bind IL-3 with low affinity, however a high affinity binding is displayed by the heterodimeric forms. Besides ligand binding, the alpha chain of IL-3R was also shown to be necessary for the activation of STAT-5. Expression of CD123 is widely found in hematopoietic cells and in addition on basophils, mast cells, and megakaryocytes. AKR, RF, A/J, and NZB mouse strains carry a 5-bp deletion in the IL-3Ra gene and thus lack the expression of CD123.
Additional information: Clone REA114 displays negligible binding to Fc receptors.

Alternative Names

IL3RA, CDw123, SUT-1

Technical specifications

  • Antigen: CD123
  • Clone: REA114
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: IL3RA, CDw123, SUT-1
  • Entrez Gene ID: 16188
  • Molecular mass of antigen [kDa]: 42
  • Distribution of antigen: B cells, basophils, bone marrow, brain, endothelial cells, eosinophils, granulocytes, leukemia cells, macrophages, mast cells, megakaryocytes, monocytes, myeloid cells, placenta, red blood cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin
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