CD120b (TNF-RII) antibodies, human

CD120b (TNF-RII) antibodies, human

Clone: REA520 | Dilution: 1:50
Clone REA520 recognizes the extracellular part of the membrane-bound form of the human CD120b antigen, a 75 kDa single-pass type I membrane protein, which is also known as tumor necrosis factor receptor type II (TNF-RII). CD120b is a receptor with high affinity for the cytokine tumor necrosis factor (TNF-α) and for lymphotoxin-alpha (LT-α). It belongs to the TNF receptor superfamily and is largely confined to cells of the immune system. CD120b is strongly expressed on stimulated T and B lymphocytes and on a variety of cells at low levels. Sustained activation of TNF signaling has been implicated in the pathogenesis of a wide spectrum of diseases, including cancer, osteoporosis, sepsis, diabetes, and autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease.
Additional information: Clone REA520 displays negligible binding to Fc receptors.

Alternative Names

TNFRSF1B, TBPII, TNFR-II, TNF-R75, Tnfbr, TNFR1B, TNFR2, TNFR80, p75, p75TNFR

Technical specifications

  • Antigen: CD120b (TNF-RII)
  • Clone: REA520
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: TNFRSF1B, TBPII, TNFR-II, TNF-R75, Tnfbr, TNFR1B, TNFR2, TNFR80, p75, p75TNFR
  • Entrez Gene ID: 7133
  • Molecular mass of antigen [kDa]: 46
  • Distribution of antigen: B cells, endothelial cells, granulocytes, hematopoietic stem cells, leukocytes, macrophages, monocytes, myeloid stem cells, NK cells, T cells, lymphocytes, thymocytes, T helper cells, NKT cells, basophils, eosinophils, cardiac muscle, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC
  • Selected References

    1. Hostager, B. S. et al. (2002) Role of TNF receptor-associated factor 2 in the activation of IgM secretion by CD40 and CD120b. J. Immunol. 168(7): 3318-3322
    2. Kohno, T. et al. (1990) A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor. Proc. Natl. Acad. Sci. U.S.A. 87(21): 8331-8335
    3. Hijdra, D. et al. (2012) Differential expression of TNFR1 (CD120a) and TNFR2 (CD120b) on subpopulations of human monocytes. J. Inflamm. 9(1): 38