CD11c antibodies, mouse

CD11c antibodies, mouse

Clone: REA754 | Dilution: 1:50
Clone REA754 recognizes the mouse CD11c antigen, also known as integrin αX or Itgax. CD11c is present in dendritic cells in lymphoid organs and blood, in Langerhans cells in the epidermis, in dendritic cell progenitors in the bone marrow, and in
in vitro
–generated bone marrow–derived dendritic cells. In spleen and lymph node, CD11c is found at high levels on conventional CD11c
dendritic cells, and at moderate levels on CD11c
plasmacytoid dendritic cells. CD11c is reported to be weakly expressed on NK cells, B cells, and T cell subsets. About 1–3% of splenocytes, 2% of bone marrow cells, as well as <1% of lymph node cells and thymocytes express CD11c. CD11c is a receptor for fibrinogen. It mediates cell-cell interaction during inflammatory responses and is involved in monocyte adhesion and chemotaxis.
Additional information: Clone REA754 displays negligible binding to Fc receptors.

Alternative Names

p150, integrin αX, ITGAX, CR4

Technical specifications

  • Antigen: CD11c
  • Clone: REA754
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: p150, integrin αX, ITGAX, CR4
  • Entrez Gene ID: 16411
  • Molecular mass of antigen [kDa]: 127
  • Distribution of antigen: B cells, dendritic cells, granulocytes, leukemia cells, lymphocytes, macrophages, monocytes, myeloid cells, NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
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