CD11c antibodies, human

CD11c antibodies, human

Clone: MJ4-27G12
This CD11 antibody reacts with human CD11c, a 145–150 kDa type I transmembrane glycoprotein, which is also known as integrin αX or CR4. It is expressed on monocytes, macrophages, NK cells, granulocytes, myeloid dendritic cells (MDCs), and subsets of T and B cells.
On myeloid dendritic cells, CD11c is highly expressed on type 1 myeloid dendritic cells (CD1c (BDCA-1)
+
CD123
low
MDC1s) and low on type 2 myeloid dendritic cells (CD1c (BDCA-1)
-
CD123
-
MDC2s).
CD11c, also known as integrin integrin αX or CR4, has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b.

Alternative Names

ITGAX, CR4, SLEB6, 95, integrin αX, p150

Technical specifications

  • Antigen: CD11c
  • Clone: MJ4-27G12
  • Isotype: mouse IgG2b
  • Isotype control: Mouse IgG2b – isotype control antibodies
  • Alternative names of antigen: ITGAX, CR4, SLEB6, 95, integrin αX, p150
  • Entrez Gene ID: 3687
  • Molecular mass of antigen [kDa]: 126
  • Distribution of antigen: B cells, dendritic cells, granulocytes, leukemia cells, lymphocytes, macrophages, monocytes, myeloid cells, NK cells, T cells
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
  • Selected references

    1. Barclay, A. N. et al. (1997) In: The Leukocyte Antigen Facts Book, Academic Press, San Diego, CA. (2nd edition): 161-162
    2. Dzionek, A. et al. (2000) BDCA-2, BDCA-3, BDCA-4: Three markers for distinct subsets of dendritic cells in human peripheral blood. J. Immunol. 165: 6037-6046
    3. Bendiss-Vermare, N. et al. (2001)
      Human thymus contains IFN-alpha-producing CD11c
      , myeloid CD11c
      +
      , and mature interdigitating dendritic cells.
      J. Clin. Invest. 107: 835-844
Product options: 1
130-108-030

CD11c pure, human

100 µg in 100 µL
-