CD117 antibodies, human

CD117 antibodies, human

Clone: REA996 | Dilution: 1:50
Clone REA996 recognizes the human CD117 antigen, also known as c-kit or SCF receptor. CD117 is a 145 kDa receptor tyrosine kinase involved in stem cell signaling, activation, and proliferation. It is expressed on about 1–3% of peripheral blood mononuclear cells (PBMCs) and cord blood cells and on up to 10% of bone marrow cells. CD117 is further expressed on basophils, myeloid dendritic cells, TCRα/β
+
T cells, CD19
+
B cells, and CD56
+
NK cells, as well as on mast cells, melanocytes, and acute myeloid leukemia (AML) blasts.
Additional information: Clone REA996 displays negligible binding to Fc receptor.

Alternative names

c-kit, KIT, PBT, SCFR

Technical specifications

  • Antigen: CD117
  • Clone: REA996
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: c-kit, KIT, PBT, SCFR
  • Entrez Gene ID: 3815
  • Molecular mass of antigen [kDa]: 107
  • Distribution of antigen: B cells, endothelial cells, fibroblasts, mast cells, megakaryocytes, NK cells, red blood cells, T cells, hematopoietic stem cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, VioBright 515, Biotin
  • Selected references

    1. Yarden, Y. et al. (1987) Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J. 6(11): 3341-3351
    2. Bühring, H. J. et al. (1991) The product of the proto-oncogene c-kit (P145c-kit) is a human bone marrow surface antigen of hematopoietic precursor cells which is expressed on a subset of acute non-lymphoblastic cells. Leukemia 5: 854-860
    3. Guth, S. et al. (1995) Immunomagnetic isolation and surface phenotyping of human c-kit receptor-expressing cells from peripheral blood. 9th International Congress of Immunology
Product options: 8
130-116-730

CD117-PE, human

for 30
tests
(1)
-
130-116-609

CD117-PE, human

for 100
tests
(1)
-
130-116-731

CD117-APC, human

for 30
tests
(1)
-
130-116-610

CD117-APC, human

for 100
tests
(1)
-
for 30
tests
(1)
-
for 100
tests
(1)
-
for 30
tests
(1)
-
for 100
tests
(1)
-

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