CD117 antibodies, human

CD117 antibodies, human

Clone: A3C6E2 | Dilution: 1:50
CD117, also known as c-kit or SCF receptor, is a 145 kDa receptor tyrosine kinase that is involved in stem cell signaling, activation, and proliferation. The CD117 antigen is expressed on about 1–3% of mononuclear cells from peripheral blood mononuclear cells (PBMCs) or cord blood, and on up to 10% of bone marrow cells. CD117 is further expressed on basophils, myeloid dendritic cells, TCRα/β
T cells, CD19
B cells, and CD56
NK cells, as well as on mast cells, melanocytes, and AML (acute myeloid leukemia) blasts.
Clone A3C6E2 recognizes a different epitope than clone AC126 and may interfere with SCF-binding. It is therefore not recommended for indirect cell isolation, but is optimal for flow cytometric analysis of cells separated with the CD117 MicroBead Kit, human.

Alternative Names

c-kit, KIT, PBT, SCFR

Technical specifications

  • Antigen: CD117
  • Clone: A3C6E2
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: c-kit, KIT, PBT, SCFR
  • Entrez Gene ID: 3815
  • Molecular mass of antigen [kDa]: 107
  • Distribution of antigen: B cells, bone marrow, brain, cancer stem cells, T cells, endothelial cells, fibroblasts, hematopoietic stem cells, kidney, leukemia cells, liver, lung, mast cells, megakaryocytes, myeloid cells, NK cells, red blood cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
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