CD116 antibodies, human

CD116 antibodies, human

Clone: REA211 | Dilution: 1:11
Clone REA211 recognizes CD116, the α subunit of GM-CSF receptor, which serves as a receptor for GM-CSF cytokine. GM-CSF is involved in innate and adaptive immune responses to infection, stimuli such as presence of LPS, and inflammatory diseases, such as asthma, rheumatoid arthritis, and multiple sclerosis. The GM-CSF receptor comprises of cytokine-specific α subunit, CD116, and βc subunit, which is a common subunit shared by interleukin-3 (IL-3) and IL-5. The human CD116 is a 378 residue glycoprotein with an extracellular N-terminal Ig-like domain, two fibronectin (FnIII) domains, and a 54 residue intracellular domain. Expression of CD116 is found on myeloid cells including monocytes, macrophages, neutrophils, eosinophils, dendritic cells, fibroblasts, endothelial cells, and myeloid leukemias.
Additional information: Clone REA211 displays negligible binding to Fc receptors.

Alternative Names

CSF2RA, GM-CSF-R-α

Technical specifications

  • Antigen: CD116
  • Clone: REA211
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CSF2RA, GM-CSF-R-α
  • Distribution of antigen: macrophages, monocytes, dendritic cells, fibroblasts, endothelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected References

    1. Kared, H. et al. (2008) Role of GM-CSF in tolerance induction by mobilized hematopoietic progenitors. Blood 112: 2575-2578
    2. Matsuguchi, T. et al. (1997) The cytoplasmic domain of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor subunit is essential for both GM-CSF-mediated growth and differentiation. J. Biol. Chem. 272: 17450-17459
Product options: 14
130-101-005

CD116-FITC, human

for 30
tests
(1)
-
130-101-001

CD116-FITC, human

for 100
tests
(1)
-
130-101-011

CD116-PE, human

for 30
tests
(1)
-
130-101-008

CD116-PE, human

for 100
tests
(1)
-
130-100-986

CD116-APC, human

for 30
tests
(1)
-
130-100-984

CD116-APC, human

for 100
tests
(1)
-
130-101-027

CD116-PE-Vio770, human

for 30
tests
(1)
-
130-101-025

CD116-PE-Vio770, human

for 100
tests
(1)
-
130-100-993

CD116-APC-Vio770, human

for 30
tests
(1)
-
130-100-992

CD116-APC-Vio770, human

for 100
tests
(1)
-
130-101-015

CD116-PerCP-Vio700, human

for 30
tests
(1)
-
130-101-014

CD116-PerCP-Vio700, human

for 100
tests
(1)
-
130-100-997

CD116-Biotin, human

for 30
tests
(1)
-
130-100-994

CD116-Biotin, human

for 100
tests
(1)
-