CD106 (VCAM-1) antibodies, rat

CD106 (VCAM-1) antibodies, rat

Clone: MR106 | Dilution: 1:10
Clone MR106 recognizes the CD106 antigen, a 110 kDa transmembrane protein also known as vascular cell adhesion protein 1 (VCAM-1). CD106 is expressed on bone marrow stromal cells, myeloid cells, and dendritic cells, but not on peripheral leukocytes. Expression on endothelial cells is upregulated upon inflammatory cytokine stimulation. CD106 is an endothelial ligand for the very late antigen-4 (VLA-4 or α4β1) of the β1 subfamily of integrins, and for integrin α4β7. It mediates the adhesion of lymphocytes, monocytes, eosinophils, and basophils to vascular endothelium. CD106 also functions in leukocyte-endothelial cell signal transduction, and it may play a role in the development of atherosclerosis and rheumatoid arthritis.

Alternative names

VCAM1, VCAM1B

Technical specifications

  • Antigen: CD106 (VCAM-1)
  • Clone: MR106
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: VCAM1, VCAM1B
  • Entrez Gene ID: 25361
  • Molecular mass of antigen [kDa]: 79
  • Distribution of antigen: endothelial cells, macrophages, dendritic cells, myeloid cells, stromal cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, Biotin
  • Selected references

    1. Hession, C. et al. (1992) Cloning of murine and rat vascular cell adhesion molecule-1. Biochem. Biophys. Res. Commun. 183(1): 163-169
    2. Barreiro, O. et al. (2002) Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes. J. Cell Biol. 157(7): 1233-1245
    3. Gao, Z. et al. (2012) Vascular endothelial growth factor participates in modulating the C6 glioma-induced migration of rat bone marrow-derived mesenchymal stem cells and upregulates their vascular cell adhesion molecule-1 expression. Exp Ther Med. 4(6): 993-998
Product options: 4
130-103-749

CD106 (VCAM-1)-PE, rat

9 µg in 300 µL (1)
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130-103-684

CD106 (VCAM-1)-PE, rat

30 µg in 1 mL (1)
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130-103-771

CD106 (VCAM-1)-Biotin, rat

9 µg in 300 µL (1)
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130-103-760

CD106 (VCAM-1)-Biotin, rat

30 µg in 1 mL (1)
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