CD101 antibodies, mouse

CD101 antibodies, mouse

Clone: REA301 | Dilution: 1:50
Clone REA301 recognizes the mouse CD101 antigen, a type I transmembrane glycoprotein also known as immunoglobulin superfamily member 2 (IgSF2) or V7. CD101 is expressed on monocytes, granulocytes, dendritic cells (DCs), and activated T cells. In humans CD101 inhibits the proliferative response of T cells to allogeneic cells or immobilized anti-CD3 antibody, suggesting that engagement of CD101 can antagonize TCR/CD3-mediated lymphocyte activation. Moreover, human peripheral CD8
+
T cells that express CD101 and CD103 display suppressive function after activation with intraepithelial cells or placental trophoblasts. In addition to its role on T cells, triggering CD101 on human cutaneous DCs inhibits T cell proliferation via interleukin 10 (IL-10) production, suggesting that the CD101 molecule may be involved in tolerance induction. Studies in mice showed that cell surface expression of CD101 is highly correlated with functional suppressor activity within CD4
+
CD25
+
T regulatory cells both
in vitro
and
in vivo
.
Additional information: Clone REA301 displays negligible binding to Fc receptors.

Alternative Names

EWI-101, Gm1016, Gm734, IGSF2

Technical specifications

  • Antigen: CD101
  • Clone: REA301
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: EWI-101, Gm1016, Gm734, IGSF2
  • Entrez Gene ID: 630146
  • Molecular mass of antigen [kDa]: 112
  • Distribution of antigen: granulocytes, monocytes, T cells, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
  • Selected References

    1. Fernandez, I. et al. (2007)
      CD101 surface expression discriminates potency among murine FoxP3
      +
      regulatory T cells.
      J. Immunol. 179(5): 2808-2814
    2. Mohammed, J. P. et al. (2011)
      Identification of CD101 as a susceptibility gene for
      Novosphingobium aromaticivorans
      -induced liver autoimmunity.
      J. Immunol. 187(1): 337-349
    3. Penha-Gonçalves, C. et al. (2003) Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice. Diabetes 52(6): 1551-1556
Product options: 1

Product information

Size
Order no.
Price

CD101-PE, mouse

  • REA301
  • 1:50
  • For research use only
30 µg in 200 µL (1)
130-120-173
-