CD101 antibodies, mouse

CD101 antibodies, mouse

Clone: REA301 | Dilution: 1:10
Clone REA301 recognizes the mouse CD101 antigen, a type I transmembrane glycoprotein also known as Immunoglobulin superfamily member 2 (IgSF2) or V7. CD101 is expressed on monocytes, granulocytes, dendritic cells (DCs), and activated T cells. In humans CD101 inhibits the proliferative response of T cells to allogeneic cells or immobilized anti-CD3 antibody, suggesting that engagement of CD101 can antagonize TCR/CD3-mediated lymphocyte activation. Moreover, human peripheral CD8
T cells that express CD101 and CD103 display suppressive function after activation with intraepithelial cells or placental trophoblasts. In addition to its role on T cells, triggering CD101 on human cutaneous DC inhibits T cell proliferation via IL-10 production, suggesting that the CD101 molecule may be involved in tolerance induction. Studies in mice showed that cell surface expression of CD101 is highly correlated with functional suppressor activity within CD4
T regulatory cells both in vitro and in vivo.
Additional information: Clone REA301 displays negligible binding to Fc receptors.

Alternative Names

EWI-101, Gm1016, Gm734, IGSF2

Technical specifications

  • Antigen: CD101
  • Clone: REA301
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: EWI-101, Gm1016, Gm734, IGSF2
  • Entrez Gene ID: 630146
  • Molecular mass of antigen [kDa]: 112
  • Distribution of antigen: granulocytes, monocytes, T cells, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin
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