Anti-ZAP70 antibodies, human

Anti-ZAP70 antibodies, human

Clone: REA814 | Dilution: 1:50
Clone REA814 recognizes the human zeta-chain-associated protein kinase 70 (ZAP70). ZAP70 plays an essential role in regulation of the adaptive immune response. It is normally expressed near the surface membrane of T cells and natural killer cells. Zap70 associates with the ζ subunit of the T cell antigen receptor and plays a critical role in T cell–signaling. It regulates both T cell–activation switch on and switch off by modulating TCR expression at the T cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection. Additionally, the ZAP70-dependent signaling pathway may also contribute to primary B cells formation and activation through the B cell receptor. Recruitment and activation of ZAP70 are transient and are terminated by phosphorylation of negative regulatory tyrosine residues and dephosphorylation of positively acting sites.
Additional information: Clone REA814 displays negligible binding to Fc receptors.

Alternative Names


Technical specifications

  • Antigen: ZAP70
  • Clone: REA814
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: ZAP-70, SRK
  • Entrez Gene ID: 7535
  • Molecular mass of antigen [kDa]: 70
  • Distribution of antigen: T cells, B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
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