Anti-TIM-1 antibodies, mouse

Anti-TIM-1 antibodies, mouse

Clone: RMT1-17 | Dilution: 1:10
Clone RMT1-17 recognizes the mouse T-cell immunoglobulin mucin receptor 1 (TIM-1) antigen, a Single-pass type I membrane protein also known as Hepatitis A virus cellular receptor 1 (HAVcr-1) or kidney injury molecule 1 (KIM-1). The TIM gene family is involved in a variety of immunity related processes including T cell proliferation and survival, tissue inflammation, and atopy. In mice, eight TIM genes encode the proteins TIM-1 to TIM-8, whereas only three TIM genes are found in humans encoding TIM-1, TIM-3, and TIM-4. Several lines of evidence suggest that TIM-1 regulates T cell activity in vivo through responses mediated by Th1, Th2, Th17, and regulatory T cells. TIM-1 is recruited to the T cell receptor signaling complex and has a costimulatory role. TIM-1 expression has been demonstrated in epithelial cells, especially those of kidney origin, and is greatly increased in both mouse and human kidneys after injury. While absent on naïve CD4 T cells, TIM-1 expression increases following TCR stimulation to provide positive co-stimulatory signal in T cell proliferation and Th1/Th17 cytokine production.

Alternative names

KIM-1, TIMD-1, HAVcr-1, TIM, TIM1

Technical specifications

  • Antigen: TIM-1
  • Clone: RMT1-17
  • Isotype: rat IgG1κ
  • Isotype control: Rat IgG1 – isotype control antibodies
  • Alternative names of antigen: KIM-1, TIMD-1, HAVcr-1, TIM, TIM1
  • Entrez Gene ID: 171283
  • Molecular mass of antigen [kDa]: 31
  • Distribution of antigen: T cells, epithelial cells, kidney
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin
  • Selected references

    1. Angiar, I. S. et al. (2014) TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity. Immunity 40(4): 542-553
    2. Feigelstock, D. et al. (1998) The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. J. Virol. 72(8): 6621-6628
    3. Moller-Tank, S. et al. (2013) Role of the phosphatidylserine receptor TIM-1 in enveloped-virus entry. J. Virol. 87(15): 8327-8341
Product options: 8
130-106-372

Anti-TIM-1-PE, mouse

9 µg in 300 µL (1)
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130-106-299

Anti-TIM-1-PE, mouse

30 µg in 1 mL (1)
-
130-106-373

Anti-TIM-1-APC, mouse

9 µg in 300 µL (1)
-
130-106-300

Anti-TIM-1-APC, mouse

30 µg in 1 mL (1)
-
130-106-374

Anti-TIM-1-PE-Vio770, mouse

9 µg in 300 µL (1)
-
130-106-301

Anti-TIM-1-PE-Vio770, mouse

30 µg in 1 mL (1)
-
130-106-371

Anti-TIM-1-Biotin, mouse

9 µg in 300 µL (1)
-
130-106-298

Anti-TIM-1-Biotin, mouse

30 µg in 1 mL (1)
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