Anti-TIM-1 antibodies, mouse

Anti-TIM-1 antibodies, mouse

Clone: REA692 | Dilution: 1:10
Clone REA692 recognizes the mouse T cell immunoglobulin mucin receptor 1 (TIM-1) antigen, a single-pass type I membrane protein, also known as hepatitis A virus cellular receptor 1 (HAVcr-1) or kidney injury molecule 1 (KIM-1). The TIM gene family is involved in a variety of immunity related processes including T cell proliferation and survival, tissue inflammation, and atopy. In mice, eight TIM genes encode the proteins TIM-1 to TIM-8, whereas only three TIM genes are found in humans encoding TIM-1, TIM-3, and TIM-4. Several lines of evidence suggest that TIM-1 regulates T cell activity
in vivo
through responses mediated by Tʜ1, Tʜ2, Tʜ17, and regulatory T cells. TIM-1 is recruited to the T cell receptor signaling complex and has a costimulatory role. TIM-1 expression has been demonstrated in epithelial cells, especially those of kidney origin, and is greatly increased in both mouse and human kidneys after injury. While absent on naive CD4 T cells, TIM-1 expression increases following TCR stimulation to provide positive co-stimulatory signal in T cell proliferation and Tʜ1/Tʜ17 cytokine production. It is reported, that the interaction of TIM-1 with TIM-4 is involved in the regulation of T cell proliferation.
Additional information: Clone REA692 displays negligible binding to Fc receptors.

Alternative Names

HAVcr-1, TIMD-1, KIM-1, TIM, TIM1

Technical specifications

  • Antigen: TIM-1
  • Clone: REA692
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: HAVcr-1, TIMD-1, KIM-1, TIM, TIM1
  • Entrez Gene ID: 171283
  • Molecular mass of antigen [kDa]: 31
  • Distribution of antigen: T cells, kidney
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, Biotin
Product options: -

Product information

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