Anti-TGF-β RII antibodies, human

Anti-TGF-β RII antibodies, human

Clone: REA903 | Dilution: 1:50
Clone REA903 recognizes the human transforming growth receptor beta 2 (TGF-β RII) antigen, a single-pass transmembrane protein belonging to the superfamily of serine/threonine kinase receptors. Members of this family bind different TGF-β cytokines (TGF-β1, TGF-β2, TGF-β3) and other growth factors and cytokine signaling proteins. The association between TGF-β RII and TGF-β2 phosphorylates proteins, that regulate the transcription of a subset of genes related to cell proliferation in the nucleus.
Additional information: Clone REA903 displays negligible binding to Fc receptors.

Alternative Names

TGF beta Receptor II, TGFR-2, TbetaR-II

Technical specifications

  • Antigen: TGF-β RII
  • Clone: REA903
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: TGF beta Receptor II, TGFR-2, TbetaR-II
  • Entrez Gene ID: 7048
  • Molecular mass of antigen [kDa]: 62
  • Distribution of antigen: macrophages, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, Biotin
  • Selected References

    1. Doré, J. J. et al. (1998) Heteromeric and homomeric transforming growth factor-beta receptors show distinct signaling and endocytic responses in epithelial cells. J. Biol. Chem. 273(48): 31770-31777
    2. Rys, J. P. et al. (2015) Discrete spatial organization of TGFβ receptors couples receptor multimerization and signaling to cellular tension. Elife
    3. Narushima, Y. et al. (2016) Integrative network analysis combined with quantitative phosphoproteomics reveals transforming growth factor-beta receptor type-2 (TGFBR2) as a novel regulator of glioblastoma stem cell properties. Mol. Cell. Proteomics 15(3): 1017-1031
Product options: 8

Product information

Size
Order no.
Price

Anti-TGF-β RII-FITC, human

  • REA903
  • 1:50
  • For research use only
for 30
tests
(1)
130-115-065
-

Anti-TGF-β RII-FITC, human

  • REA903
  • 1:50
  • For research use only
for 100
tests
(1)
130-115-023
-

Anti-TGF-β RII-PE, human

  • REA903
  • 1:50
  • For research use only
for 30
tests
(1)
130-115-066
-

Anti-TGF-β RII-PE, human

  • REA903
  • 1:50
  • For research use only
for 100
tests
(1)
130-115-024
-

Anti-TGF-β RII-APC, human

  • REA903
  • 1:50
  • For research use only
for 30
tests
(1)
130-115-067
-

Anti-TGF-β RII-APC, human

  • REA903
  • 1:50
  • For research use only
for 100
tests
(1)
130-115-025
-

Anti-TGF-β RII-Biotin, human

  • REA903
  • 1:50
  • For research use only
for 30
tests
(1)
130-115-064
-

Anti-TGF-β RII-Biotin, human

  • REA903
  • 1:50
  • For research use only
for 100
tests
(1)
130-115-022
-