Anti-TCR Vγ9 antibodies, human

Anti-TCR Vγ9 antibodies, human

Clone: REA470 | Dilution: 1:11
Clone REA470 recognizes the human variable gamma 9 subunit of the γ/δ T cell receptor (TCR Vγ9). The T cell receptor is a heterodimeric glycoprotein associated with the CD3 antigen. The γ and δ TCR chains are composed of constant and variable regions, each encoded by distinct gene segments. γδ T cells represent unconventional lymphocytes that share characteristics of NK cells and T cells and often express regulatory NK receptors, thereby linking innate and adaptive immunity. Upon cross-linking CD94/NKG2A, antigenic activation of γδ T cells is down-modulated by inhibiting cell proliferation, cytokine production, and cytotoxicity. γδ T cells can detect target cells with patterns of MHC class I expression altered as a result of tumor transformation or viral infection, thus endowing them with a role in immunosurveillance originally attributed to NK cells only. Vγ9/Vδ2 T cells comprise the majority of peripheral human γδ T cells and are capable of responding to the microbial metabolite HMB-PP.
Additional information: Clone REA470 displays negligible binding to Fc receptors.

Technical specifications

  • Antigen: TCR Vγ9
  • Clone: REA470
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Entrez Gene ID: 6983
  • Molecular mass of antigen [kDa]: 13
  • Cross-reactivity:
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    chimpanzee (
    Pan troglodytes
    )
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, APC-Vio770, Biotin
Product options: 12

Product information

Size
Order no.
Price

Anti-TCR Vγ9-FITC, human

  • REA470
  • 1:11
  • For research use only
for 30
tests
(1)
130-107-487
-

Anti-TCR Vγ9-FITC, human

  • REA470
  • 1:11
  • For research use only
for 100
tests
(1)
130-107-433
-

Anti-TCR Vγ9-PE, human

  • REA470
  • 1:11
  • For research use only
for 30
tests
(1)
130-107-488
-

Anti-TCR Vγ9-PE, human

  • REA470
  • 1:11
  • For research use only
for 100
tests
(1)
130-107-434
-

Anti-TCR Vγ9-APC, human

  • REA470
  • 1:11
  • For research use only
for 30
tests
(1)
130-107-489
-

Anti-TCR Vγ9-APC, human

  • REA470
  • 1:11
  • For research use only
for 100
tests
(1)
130-107-435
-

Anti-TCR Vγ9-VioBlue, human

  • REA470
  • 1:11
  • For research use only
for 30
tests
(1)
130-107-486
-

Anti-TCR Vγ9-VioBlue, human

  • REA470
  • 1:11
  • For research use only
for 100
tests
(1)
130-107-432
-

Anti-TCR Vγ9-APC-Vio770, human

  • REA470
  • 1:11
  • For research use only
for 30
tests
(1)
130-107-490
-

Anti-TCR Vγ9-APC-Vio770, human

  • REA470
  • 1:11
  • For research use only
for 100
tests
(1)
130-107-436
-

Anti-TCR Vγ9-Biotin, human

  • REA470
  • 1:11
  • For research use only
for 30
tests
(1)
130-107-485
-

Anti-TCR Vγ9-Biotin, human

  • REA470
  • 1:11
  • For research use only
for 100
tests
(1)
130-107-431
-

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