Anti-TCR Vβ5 antibodies, human

Anti-TCR Vβ5 antibodies, human

Clone: REA910 | Dilution: 1:50
Clone REA910 recognizes the human variable β 5 subunit of the αβ T cell receptor (TCR Vβ5). The TCR is a heterodimeric glycoprotein associated with the CD3 antigen. The α and β TCR chains are composed of constant and variable regions, each encoded by distinct gene segments. TCR Vβ5 is a variant of the TCR β chain. αβ T cells express a diverse αβ TCR repertoire that specifically co-recognizes self or foreign antigen bound to antigen-presenting molecules, which thereby leads to T cell–mediated immunity. For example, the TCR can directly bind to peptide fragments, riboflavin precursors, and lipid antigens that are presented by major histocompatibility complex (MHC) molecules, MR1 and CD1, respectively. In each case, the antigen sits within the antigen-binding cleft, whereupon the TCR recognizes a composite surface formed by the antigen-presenting molecule and surface-exposed regions of the antigen itself. This co-recognition paradigm is a central tenet of αβ T cell–mediated immunity and underpins MHC restriction.
Additional information: Clone REA910 displays negligible binding to Fc receptors.

Alternative Names

TCR Vb5, TCR Vbeta5

Technical specifications

  • Antigen: TCR Vβ5
  • Clone: REA910
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: TCR Vb5, TCR Vbeta5
  • Entrez Gene ID: 28614, 28613
  • Molecular mass of antigen [kDa]: 10
  • Cross-reactivity: pigtailed macaque
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected References

    1. Wei, S. et al. (1994) The extent of the human germline T-cell receptor V beta gene segment repertoire. Immunogenetics 40(1): 27-36
    2. Killestein, J. et al. (2002)
      Antibody-mediated suppression of Vbeta5.2/5.3
      +
      T cells in multiple sclerosis: results from an MRI-monitored phase II clinical trial.
      Ann. Neurol. 51(4): 467-474
    3. Joedicke, J. J. et al. (2014)
      Activated CD8
      +
      T cells induce expansion of Vβ5
      +
      regulatory T cells via TNFR2 signaling.
      J. Immunol. 193(6): 2952-2960

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