Anti-TCR Vβ23 antibodies, human

Anti-TCR Vβ23 antibodies, human

Clone: REA497 | Dilution: 1:11
Clone REA497 recognizes the human variable beta 23 subunit of the αβ T cell receptor (TCR Vβ23). The TCR is a heterodimeric glycoprotein associated with the CD3 antigen. The α and β TCR chains are composed of constant and variable regions, each encoded by distinct gene segments. TCR Vβ23 is a variant of the TCR β chain. αβ T cells express a diverse αβ TCR repertoire that specifically co-recognizes self or foreign antigen bound to antigen-presenting molecules, which thereby leads to T cell–mediated immunity. For example, the TCR can directly bind to peptide fragments, riboflavin precursors, and lipid antigens that are presented by major histocompatibility complex (MHC) molecules, MR1 and CD1, respectively. In each case, the antigen sits within the antigen-binding cleft, whereupon the TCR recognizes a composite surface formed by the antigen-presenting molecule and surface-exposed regions of the antigen itself. This co-recognition paradigm is a central tenet of αβ T cell–mediated immunity and underpins MHC restriction.
Additional information: Clone REA497 displays negligible binding to Fc receptors.

Technical specifications

  • Antigen: TCR Vβ23
  • Clone: REA497
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Entrez Gene ID: 28564
  • Molecular mass of antigen [kDa]: 13
  • Distribution of antigen: T cells, thymocytes, T helper cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, APC-Vio770, Biotin
Product options: 10

Product information

Size
Order no.
Price

Anti-TCR Vβ23-FITC, human

  • REA497
  • 1:11
  • For research use only
for 30
tests
(1)
130-107-495
-

Anti-TCR Vβ23-FITC, human

  • REA497
  • 1:11
  • For research use only
for 100
tests
(1)
130-107-441
-

Anti-TCR Vβ23-PE, human

  • REA497
  • 1:11
  • For research use only
for 30
tests
(1)
130-107-496
-

Anti-TCR Vβ23-PE, human

  • REA497
  • 1:11
  • For research use only
for 100
tests
(1)
130-107-442
-

Anti-TCR Vβ23-APC, human

  • REA497
  • 1:11
  • For research use only
for 30
tests
(1)
130-107-497
-

Anti-TCR Vβ23-APC, human

  • REA497
  • 1:11
  • For research use only
for 100
tests
(1)
130-107-443
-

Anti-TCR Vβ23-APC-Vio770, human

  • REA497
  • 1:11
  • For research use only
for 30
tests
(1)
130-107-498
-

Anti-TCR Vβ23-APC-Vio770, human

  • REA497
  • 1:11
  • For research use only
for 100
tests
(1)
130-107-444
-

Anti-TCR Vβ23-Biotin, human

  • REA497
  • 1:11
  • For research use only
for 30
tests
(1)
130-107-494
-

Anti-TCR Vβ23-Biotin, human

  • REA497
  • 1:11
  • For research use only
for 100
tests
(1)
130-107-440
-

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