Anti-TCR Vβ21.3 antibodies, human

Anti-TCR Vβ21.3 antibodies, human

Clone: REA894 | Dilution: 1:50
Clone REA894 recognizes the human β 21.3 subunit of the αβ T cell receptor (TCR Vβ21.3). The TCR is a disulfide-linked membrane-anchored heterodimeric protein associated with the CD3 antigen. The α and β TCR chains are composed of constant and variable regions, each encoded by distinct gene segments. TCR Vβ21.3 is a variant of the TCR β chain. αβ T cells express a diverse αβ TCR repertoire that specifically co-recognizes self or foreign antigen bound to antigen-presenting molecules, which thereby leads to T cell–mediated immunity. For example, the TCR can directly bind to peptide fragments, riboflavin precursors, and lipid antigens that are presented by major histocompatibility complex (MHC) molecules, MR1 and CD1, respectively. In each case, the antigen sits within the antigen-binding cleft, whereupon the TCR recognizes a composite surface formed by the antigen-presenting molecule and surface-exposed regions of the antigen itself. This co-recognition paradigm is a central tenet of αβ T cell–mediated immunity and underpins MHC restriction.
Additional information: Clone REA894 displays negligible binding to Fc receptors.

Alternative Names

TCR Vbeta21.3, TCR V beta 21.3, TCR Vb21.3

Technical specifications

  • Antigen: TCR Vβ21.3
  • Clone: REA894
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: TCR Vbeta21.3, TCR V beta 21.3, TCR Vb21.3
  • Entrez Gene ID: 28581
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, Biotin
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