Anti-TCR Vα7.2 antibodies, human

Anti-TCR Vα7.2 antibodies, human

Clone: REA179 | Dilution: 1:11
Clone REA179 recognizes the TCR chain Vα7.2, which together with Jα33 segment forms the invariant T cell receptor. Human Vα7.2-Jα33 invariant T cells are preferentially localized in the gut and are often termed as mucosal-associated T (MAIT) cells. MAIT cells are restricted to MHC class I like molecules, such as MR1. Further, MAIT cells are suggested to be involved in regulation of immune response at the mucosal surfaces, which are the primary sites for pathogen entry.
Additional information: Clone REA179 displays negligible binding to Fc receptors.

Alternative names

TRA, IMD7, TCRA, TCRD, TRAC, TCRAV7S1, TRAV7

Technical specifications

  • Antigen: TCR Vα7.2
  • Clone: REA179
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: TRA, IMD7, TCRA, TCRD, TRAC, TCRAV7S1, TRAV7
  • Entrez Gene ID: 28686
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, APC, VioBlue, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin

Specificity

In order to compare the epitope specificity of REAfinity Clone REA179 with other known clones, a competition assay was performed.
 Cells were incubated with an excess of purified unconjugated REAfinity Antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.
 

Other clonesOverlap in epitope recognition with REA179
3C10++
  • Selected references

    1. Treiner, E. et al. (2003) Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1. Nature 422(6928): 164-169
    2. Wang, Y. et al. Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations. J. Exp. Med. 213(11)
    3. Qualai, J. et al. (2016) Expression of CD11c is associated with unconventional activated T cell subsets with high migratory potential. PLoS One 11
    4. Gold, M. C. and Lewinsohn, D. M. (2013) Co-dependents: MR1-restricted MAIT cells and their antimicrobial function. Nat. Rev. Microbiol. 11(1): 14-19
Product options: 14
130-100-190

Anti-TCR Vα7.2-FITC, human

for 30
tests
(1)
-
130-100-189

Anti-TCR Vα7.2-FITC, human

for 100
tests
(1)
-
130-100-178

Anti-TCR Vα7.2-APC, human

for 30
tests
(1)
-
130-100-177

Anti-TCR Vα7.2-APC, human

for 100
tests
(1)
-
130-100-211

Anti-TCR Vα7.2-VioBlue, human

for 30
tests
(1)
-
130-100-209

Anti-TCR Vα7.2-VioBlue, human

for 100
tests
(1)
-
130-100-207

Anti-TCR Vα7.2-PE-Vio770, human

for 30
tests
(1)
-
130-100-206

Anti-TCR Vα7.2-PE-Vio770, human

for 100
tests
(1)
-
130-100-180

Anti-TCR Vα7.2-APC-Vio770, human

for 30
tests
(1)
-
130-100-179

Anti-TCR Vα7.2-APC-Vio770, human

for 100
tests
(1)
-
130-100-204

Anti-TCR Vα7.2-PerCP-Vio700, human

for 30
tests
(1)
-
130-100-203

Anti-TCR Vα7.2-PerCP-Vio700, human

for 100
tests
(1)
-
130-100-188

Anti-TCR Vα7.2-Biotin, human

for 30
tests
(1)
-
130-100-187

Anti-TCR Vα7.2-Biotin, human

for 100
tests
(1)
-