Anti-TCR Vα11.1, 11.2 antibodies, mouse

Anti-TCR Vα11.1, 11.2 antibodies, mouse

Clone: REA464 | Dilution: 1:10
Clone REA464 recognizes the mouse V alpha 11.1 and 11.2 T cell receptor (TCR Vα11.1, 11.2) of mice having the b (e.g., C57BL/6) and d (e.g., DBA/1, DBA/2, NZW) haplotypes, but not with the strains having the a (Balb/c) or c (e.g., SJL, NOD) haplotype. The TCR is responsible for recognizing antigens bound to major histocompatibility complex (MHC) molecules. It is a disulfide-linked membrane-anchored heterodimeric glycoprotein normally consisting of the highly variable alpha and beta chains expressed as part of a complex with the invariant CD3 chain molecules. TCR Vα elements are expressed preferentially in CD4 or CD8 subsets in a manner that is largely independent of the MHC haplotype. It is likely that the Vα elements interact preferentially with conserved regions of class I or class II molecules.
Additional information: Clone REA464 displays negligible binding to Fc receptors.

Alternative names

TCRA, AV11S2, Va11.2, Va11.2b, AV11S1, Va11.1, Va11.1b, TCR-Va11.1, 11.2

Technical specifications

  • Antigen: TCR Vα11.1, 11.2
  • Clone: REA464
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: TCRA, AV11S2, Va11.2, Va11.2b, AV11S1, Va11.1, Va11.1b, TCR-Va11.1, 11.2
  • Entrez Gene ID: 110584, 110583, 21473
  • Molecular mass of antigen [kDa]: 16
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Nakajima, P. B. et al. (1992) Chromosome 14 in B10.A(18R) mice is recombinant and includes Tcra-Va alleles. Immunogenetics 35(3): 190-198
    2. Osman, G. E. et al. (1998) Expression of a type II collagen-specific TCR transgene accelerates the onset of arthritis in mice. Int. Immunol. 10(11): 1613-1622
    3. Osman, G. E. et al. (1999) T-cell receptor vbeta deletion and valpha polymorphism are responsible for the resistance of SWR mouse to arthritis induction. Immunogenetics 49(9): 764-772
Product options: 10
130-107-001

Anti-TCR Vα11.1, 11.2-PE, mouse

9 µg in 300 µL (1)
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130-106-940

Anti-TCR Vα11.1, 11.2-PE, mouse

30 µg in 1 mL (1)
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130-107-002

Anti-TCR Vα11.1, 11.2-APC, mouse

9 µg in 300 µL (1)
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130-106-941

Anti-TCR Vα11.1, 11.2-APC, mouse

30 µg in 1 mL (1)
-
130-107-003

Anti-TCR Vα11.1, 11.2-PE-Vio770, mouse

9 µg in 300 µL (1)
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130-106-942

Anti-TCR Vα11.1, 11.2-PE-Vio770, mouse

30 µg in 1 mL (1)
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130-107-004

Anti-TCR Vα11.1, 11.2-APC-Vio770, mouse

9 µg in 300 µL (1)
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130-106-943

Anti-TCR Vα11.1, 11.2-APC-Vio770, mouse

30 µg in 1 mL (1)
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130-107-000

Anti-TCR Vα11.1, 11.2-Biotin, mouse

9 µg in 300 µL (1)
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130-106-939

Anti-TCR Vα11.1, 11.2-Biotin, mouse

30 µg in 1 mL (1)
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