Anti-TCL1 antibodies, human

Anti-TCL1 antibodies, human

Clone: REA289 | Dilution: 1:10
Clone REA289 recognizes the T cell leukemia/lymphoma protein, a 14 kDa symmetrical b-barrel structure protein also known as oncogene TCL-1 or protein p14 TCL1. The TCL1 locus on chromosome 14q32.1 is frequently involved in chromosomal translocations and inversions with one of the T cell receptor loci in human T cell leukemias and lymphomas. In the lymphoid compartment, TCL1 expression is limited to CD4
-
CD8
-
CD3
-
thymocytes, CD34
+
CD19
+
pro–B cell through IgM-negative pre–B cells, as well as plasmacytoid subset of dendritic cells. The members of the TCL1 proto-oncogene family (TCL1, MTCP1, and TCL1b) bind to Akt1, increasing its phosphorylation status and kinase activity. Further, TCL1 is able to promote the formation of oligomeric TCL1-Akt protein complexes in which the kinase is preferentially phosphorylated and activated.
Additional information: Clone REA289 displays negligible binding to Fc receptors.

Alternative names

TCL1A, SYN-1, TML1, TCL1B

Technical specifications

  • Antigen: TCL1
  • Clone: REA289
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: TCL1A, SYN-1, TML1, TCL1B
  • Distribution of antigen: thymocytes, B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770
  • Selected references

    1. Virgilio, L. et al. (1994) Identification of the TCL1 gene involved in T-cell malignancies. Proc. Natl. Acad. Sci. U.S.A. 91(26): 12530-12534
    2. Laine, J. et al. (2000) The protooncogene TCL1 is an Akt kinase coactivator. Mol. Cell 6(2): 395-407
    3. Laine, J. et al. (2002) Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. J. Biol. Chem. 277(5): 3743-3751
Product options: 10
130-104-132

Anti-TCL1-FITC, human

for 30
tests
(1)
-
130-104-094

Anti-TCL1-FITC, human

for 100
tests
(1)
-
130-104-133

Anti-TCL1-PE, human

for 30
tests
(1)
-
130-104-095

Anti-TCL1-PE, human

for 100
tests
(1)
-
130-104-134

Anti-TCL1-APC, human

for 30
tests
(1)
-
130-104-096

Anti-TCL1-APC, human

for 100
tests
(1)
-
130-104-135

Anti-TCL1-PE-Vio770, human

for 30
tests
(1)
-
130-104-097

Anti-TCL1-PE-Vio770, human

for 100
tests
(1)
-
130-104-136

Anti-TCL1-APC-Vio770, human

for 30
tests
(1)
-
130-104-098

Anti-TCL1-APC-Vio770, human

for 100
tests
(1)
-