Anti-Syk pY348 antibodies, human

Anti-Syk pY348 antibodies, human

Clone: REA681 | Dilution: 1:11
Clone REA681 recognizes Syk protein phosphorylated at tyrosine 348. Syk is a 72 kDa non–receptor tyrosine kinase cytoplasmic protein. Syk belongs to the SYK/ZAP 70 family of tyrosine protein kinases and is mainly expressed in hematopoietic cells. Activated immunoreceptors, phosphorylated at ITAM motifs recruit Syk from the cytoplasm to the signalosome complex at the perimembrane location. Syk, upon binding of SH2 domains to immunoreceptor ITAM is activated and undergoes autophosphorylation and phosphorylation by SRC kinases. Activated Syk catalyzes tyrosine phosphorylation of multiple downstream proteins which regulate signaling pathways such AKT, MAP kinase, and NF-κB. A wide variety of cellular and physiological functions such as cell activation and differentiation are regulated by Syk. Phosphorylation at Tyr-348 creates a binding site for VAV1.
Additional information: Clone REA681 displays negligible binding to Fc receptors.

Alternative Names

Tyrosine-protein kinase SYK

Technical specifications

  • Antigen: Syk pY348
  • Clone: REA681
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: Tyrosine-protein kinase SYK
  • Entrez Gene ID: 6850
  • Molecular mass of antigen [kDa]: 72
  • Cross-reactivity: mouse
  • Distribution of antigen: B cells, T cells, myeloid cells, breast cancer cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
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