Anti-STAT5a antibodies, human

Anti-STAT5a antibodies, human

Clone: REA549 | Dilution: 1:11
Clone REA549 recognizes the human STAT5a antigen, a member of signal transducers and activators of the transcription (STAT) family. The seven STAT family members play a critical role in activation of signaling pathways in response to the presence of various cytokines and growth factors (interferon (IFN)-α, IFN-γ, EGF, PDGF, and interleukin (IL)-6). STAT5a regulates the expression of milk proteins during lactation and mediates cellular responses to the receptor tyrosine-protein kinase ERBB4. It may induce cellular responses to activated FGFR1, FGFR2, FGFR3, and FGFR4. Among others STAT5a is expressed in prostate and breast cancer.
Additional information: Clone REA549 displays negligible binding to Fc receptors.

Alternative names

MGF, STAT5

Technical specifications

  • Antigen: STAT5a
  • Clone: REA549
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: MGF, STAT5
  • Entrez Gene ID: 6776
  • Molecular mass of antigen [kDa]: 91
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
  • Selected references

    1. Lin, J. X. et al. (2000) The role of Stat5a and Stat5b in signaling by IL-2 family cytokines. Oncogene 19(21): 2566-2576
    2. Aoki, N. et al. (2002) A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus. Mol Endocrinol. 16(1): 58-69
    3. Williams, C. C. et al. (2004) The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone. J. Cell Biol. 167(3): 469-478
Product options: 6
for 30
tests
(1)
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for 100
tests
(1)
-
for 30
tests
(1)
-
for 100
tests
(1)
-
for 30
tests
(1)
-
for 100
tests
(1)
-

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