Anti-STAT4 pY693 antibodies, human

Anti-STAT4 pY693 antibodies, human

Clone: REA855 | Dilution: 1:50
Clone REA855 recognizes the human signal transducer and activator of transcription 4 (STAT4) antigen phosphorylated at tyrosine 693 (pY693). STAT4 is a member of signal transducers and activators of the transcription (STAT) family. STAT proteins transmit signals from a receptor complex to the nucleus and activate gene expression. The seven STAT family members play a critical role in activation of signaling pathways in response to the presence of various cytokines and growth factors (interferon α (IFN-α), interferon γ (IFN-γ), EGF, PDGF, and interleukin 6 (IL-6)). STAT4 is involved in the development of Tʜ1 cells from naive CD4
+
T cells and IFN-γ production in response to IL-12.
Additional information: Clone REA855 displays negligible binding to Fc receptors.

Technical specifications

  • Antigen: STAT4 pY693
  • Clone: REA855
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Entrez Gene ID: 6775
  • Molecular mass of antigen [kDa]: 86
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, Vio515
  • Selected References

    1. Yamamoto, K. et al. (1994) Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation. Mol. Cell. Biol. 14(7): 4342-4349
    2. Bacon, C. M. et al. (1995) Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 92(16): 7307-7311
    3. Kaplan, M. H. (2005)
      STAT4: a critical regulator of inflammation
      in vivo
      .
      Immunol. Res. 31(3): 231-242
Product options: 8
130-114-682

Anti-STAT4 pY693-FITC, human

for 30
tests
(1)
-
130-114-491

Anti-STAT4 pY693-FITC, human

for 100
tests
(1)
-
130-114-683

Anti-STAT4 pY693-PE, human

for 30
tests
(1)
-
130-114-492

Anti-STAT4 pY693-PE, human

for 100
tests
(1)
-
130-114-684

Anti-STAT4 pY693-APC, human

for 30
tests
(1)
-
130-114-493

Anti-STAT4 pY693-APC, human

for 100
tests
(1)
-
130-114-685

Anti-STAT4 pY693-Vio515, human

for 30
tests
(1)
-
130-114-494

Anti-STAT4 pY693-Vio515, human

for 100
tests
(1)
-