Anti-STAT1 N-terminus antibodies, human

Anti-STAT1 N-terminus antibodies, human

Clone: REA272 | Dilution: 1:11
Clone REA272 recognizes the N-terminus of the signal transducer and activator of transcription 1-α/β (STAT1) antigen, regardless of phosphorylation status. STAT1 is expressed in two alternatively spliced isoforms (91 kDa STAT1α and 84 kDa STAT1β) and clone REA272 recognizes both isoforms. STAT1 expression is found ubiquitously. It is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. In response to interferon γ (IFN-γ) stimulation, the STAT1 subunits become tyrosine-phosphorylated at Y701, and the complex is translocated to the nucleus. STAT1 forms homodimers or heterodimers with STAT3 that bind to the IFN-γ activated sequence promoter element. In response to either IFN-α or IFN-β stimulation, STAT1 forms a heterodimer with STAT2 that can bind the interferon stimulated response promoter element. In either case, binding of the promoter element leads to an increased expression of interferon stimulated genes.
Additional information: Clone REA272 displays negligible binding to Fc receptors.

Alternative names

CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91

Technical specifications

  • Antigen: STAT1 N-terminus
  • Clone: REA272
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91
  • Entrez Gene ID: 6772
  • Molecular mass of antigen [kDa]: 87
  • Cross-reactivity: mouse, rat, dog, chicken, frog
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Mowen, K. et al. (1998) Role of the STAT1-SH2 domain and STAT2 in the activation and nuclear translocation of STAT1. J. Biol. Chem. 273: 30073-30076
    2. ten Hoeve, J. et al. (2002) Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol. Cell. Biol. 16: 5662-5668
    3. Sikorski, K. et al. (2011) STAT1-mediated signal integration between IFNγ and LPS leads to increased EC and SMC activation and monocyte adhesion. Am. J. Physiol., Cell Physiol. 300: C1337-C1344
    4. Gimeno, R. et al. (1996)
      STAT1 implication in the immune response to superantigens
      in vivo.
      J. Immunol. 156: 1378-1386
Product options: 4
for 30
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(1)
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for 100
tests
(1)
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for 30
tests
(1)
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for 100
tests
(1)
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