Anti-Siglec-H antibodies, mouse

Anti-Siglec-H antibodies, mouse

Clone: REA819 | Dilution: 1:50
Clone REA819 recognizes the mouse siglec-H antigen, a 34 kDa transmembrane protein of the Ig superfamily known as mouse sialic acid-binding immunoglobulin-like lectin. Siglec-H is specifically expressed on mouse plasmacytoid dendritic cells, a subset of CD11c
+
dendritic cells detected at low frequency in all lymphoid tissues, peripheral blood, and some non-lymphoid tissues. Binding of antibodies to siglec-H inhibits type I interferon production, which can be induced in plasmacytoid dendritic cells by DNA and RNA viruses.
Additional information: Clone REA819 displays negligible binding to Fc receptors.

Alternative Names

SIGLECH

Technical specifications

  • Antigen: Siglec-H
  • Clone: REA819
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: SIGLECH
  • Entrez Gene ID: 233274
  • Molecular mass of antigen [kDa]: 37
  • Distribution of antigen: dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected References

    1. Lund, J. et al. (2003) Toll-like receptor 9–mediated recognition of herpes simplex virus-2 by plasmacytoid dendritic cells. J. Exp. Med. 198(3): 513-520
    2. Blasius, A. et al. (2004) A cell-surface molecule selectively expressed on murine natural interferon-producing cells that blocks secretion of interferon-alpha. Blood 103(11): 4201-4206
    3. Blasius, A. L. et al. (2006) Siglec-H is an IPC-specific receptor that modulates type I IFN secretion through DAP12. Blood 107(6): 2474-2476
Product options: 12

Product information

Size
Order no.
Price

Anti-Siglec-H-FITC, mouse

  • REA819
  • 1:50
  • For research use only
30 µg in 200 µL (1)
130-112-300
-

Anti-Siglec-H-FITC, mouse

  • REA819
  • 1:50
  • For research use only
150 µg in 1 mL (1)
130-112-142
-

Anti-Siglec-H-PE, mouse

  • REA819
  • 1:50
  • For research use only
30 µg in 200 µL (1)
130-112-296
-

Anti-Siglec-H-PE, mouse

  • REA819
  • 1:50
  • For research use only
150 µg in 1 mL (1)
130-112-138
-

Anti-Siglec-H-APC, mouse

  • REA819
  • 1:50
  • For research use only
30 µg in 200 µL (1)
130-112-297
-

Anti-Siglec-H-APC, mouse

  • REA819
  • 1:50
  • For research use only
150 µg in 1 mL (1)
130-112-139
-

Anti-Siglec-H-PE-Vio770, mouse

  • REA819
  • 1:50
  • For research use only
30 µg in 200 µL (1)
130-112-298
-

Anti-Siglec-H-PE-Vio770, mouse

  • REA819
  • 1:50
  • For research use only
150 µg in 1 mL (1)
130-112-140
-

Anti-Siglec-H-APC-Vio770, mouse

  • REA819
  • 1:50
  • For research use only
30 µg in 200 µL (1)
130-112-299
-

Anti-Siglec-H-APC-Vio770, mouse

  • REA819
  • 1:50
  • For research use only
150 µg in 1 mL (1)
130-112-141
-

Anti-Siglec-H-Biotin, mouse

  • REA819
  • 1:50
  • For research use only
30 µg in 200 µL (1)
130-112-293
-

Anti-Siglec-H-Biotin, mouse

  • REA819
  • 1:50
  • For research use only
150 µg in 1 mL (1)
130-112-135
-