Anti-Siglec-8 antibodies, human

Anti-Siglec-8 antibodies, human

Clone: REA1045 | Dilution: 1:50
Clone REA1045 recognizes siglec-8, a 54 kDa type I transmembrane protein, which is a member of the Ig superfamily. Though it is mainly expressed by eosinophils, expression of siglec-8 is also found on basophils and mast cells. It has been reported that siglec-8 cross-linking with antibodies reduces eosinophil viability through induction of apoptosis.
Additional information: Clone REA1045 displays negligible binding to Fc receptors.

Alternative Names

SAF2, SIGLEC8L

Technical specifications

  • Antigen: Siglec-8
  • Clone: REA1045
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: SAF2, SIGLEC8L
  • Entrez Gene ID: 27181
  • Molecular mass of antigen [kDa]: 52
  • Distribution of antigen: basophils, eosinophils, mast cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, PE-Vio770, Biotin
  • Selected References

    1. Kikly, K. K. et al. (2000) Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils. J. Allergy Clin. Immunol. 105: 1093-1100
    2. Nutku, E. et al. (2003) Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis. Blood 101: 5014-5020
    3. Hudson, S. A. et al. (2011) Developmental, malignancy-related, and cross-species analysis of eosinophil, mast cell, and basophil siglec-8 expression. J. Clin. Immunol. 31(6): 1045-1053
Product options: 12
130-117-973

Anti-Siglec-8-FITC, human

for 30
tests
(1)
-
130-117-900

Anti-Siglec-8-FITC, human

for 100
tests
(1)
-
130-117-974

Anti-Siglec-8-PE, human

for 30
tests
(1)
-
130-117-901

Anti-Siglec-8-PE, human

for 100
tests
(1)
-
130-117-975

Anti-Siglec-8-APC, human

for 30
tests
(1)
-
130-117-902

Anti-Siglec-8-APC, human

for 100
tests
(1)
-
130-117-976

Anti-Siglec-8-PE-Vio615, human

for 30
tests
(1)
-
130-117-903

Anti-Siglec-8-PE-Vio615, human

for 100
tests
(1)
-
130-117-977

Anti-Siglec-8-PE-Vio770, human

for 30
tests
(1)
-
130-117-904

Anti-Siglec-8-PE-Vio770, human

for 100
tests
(1)
-
130-117-980

Anti-Siglec-8-Biotin, human

for 30
tests
(1)
-
130-117-907

Anti-Siglec-8-Biotin, human

for 100
tests
(1)
-