Anti-Siglec-8 antibodies, human

Anti-Siglec-8 antibodies, human

Clone: 7C9 | Dilution: 1:11
The monoclonal antibody 7C9 recognizes siglec-8, a 54 kDa type I transmembrane protein, which is a member of the Ig superfamily. Though it is mainly expressed by eosinophils, expression of siglec-8 is also found on basophils and mast cells. It has been reported that siglec-8 cross-linking with antibodies reduces eosinophil viability through induction of apoptosis.

Alternative Names

SAF2, SIGLEC8L

Technical specifications

  • Antigen: Siglec-8
  • Clone: 7C9
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: SAF2, SIGLEC8L
  • Entrez Gene ID: 27181
  • Molecular mass of antigen [kDa]: 52
  • Distribution of antigen: B cells, bone marrow, granulocytes, leukocytes, liver, monocytes, neutrophils, NK cells, placenta, spleen, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, Biotin
  • Selected References

    1. Nutku, E. et al. (2003) Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis. Blood 101: 5014-5020
    2. Hudson, S. A. et al. (2011) Developmental, malignancy-related, and cross-species analysis of eosinophil, mast cell, and basophil siglec-8 expression. J. Clin. Immunol. 31(6): 1045-1053
    3. Kikly, K. K. et al. (2000) Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils. J. Allergy Clin. Immunol. 105: 1093-1100
Product options: 10
130-098-716

Anti-Siglec-8-FITC, human

for 30
tests
(1)
-
130-098-715

Anti-Siglec-8-FITC, human

for 100
tests
(1)
-
130-098-727

Anti-Siglec-8-PE, human

for 30
tests
(1)
-
130-098-725

Anti-Siglec-8-PE, human

for 100
tests
(1)
-
130-098-731

Anti-Siglec-8-APC, human

for 30
tests
(1)
-
130-098-729

Anti-Siglec-8-APC, human

for 100
tests
(1)
-
130-105-576

Anti-Siglec-8-PE-Vio770, human

for 30
tests
(1)
-
130-105-524

Anti-Siglec-8-PE-Vio770, human

for 100
tests
(1)
-
130-098-714

Anti-Siglec-8-Biotin, human

for 30
tests
(1)
-
130-098-712

Anti-Siglec-8-Biotin, human

for 100
tests
(1)
-