Anti-Siglec-5/Siglec-14 antibodies, human

Anti-Siglec-5/Siglec-14 antibodies, human

Clone: REA393 | Dilution: 1:11
Clone REA393 recognizes the human siglec-5 and siglec-14 antigens, which are both single pass transmembrane protein members of the immunoglobulin superfamily. Siglec-5 is also known as CD170. Siglec-5 has four extracellular Ig-like domains and a cytosolic inhibitory motif. Siglec-14 was discovered with three Ig-like domains and has almost complete sequence identity with siglec-5 at the first two Ig-like domains, shows a glycan binding preference similar to that of siglec-5, and associates with the activating adapter protein DAP12. Siglec-5 is expressed on granulocytes and monocytes as well as on plasmacytoid dendritic cells, monocyte-derived dendritic cells, and macrophages. It is potentially involved in the negative regulation of innate immune responses, and also suggested to be a useful diagnostic and therapeutic marker for acute myelogenous leukemia. Siglec-14 is expressed on granulocytes and B cells. Some individuals lack the expression of siglec-14, while they all express siglec-5.
Additional information: Clone REA393 displays negligible binding to Fc receptors.

Alternative Names

CD170, CD33L2, OB-BP2, OBBP2, SIGLEC5, Siglec14

Technical specifications

  • Antigen: Siglec-5/Siglec-14
  • Clone: REA393
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CD170, CD33L2, OB-BP2, OBBP2, SIGLEC5, Siglec14
  • Entrez Gene ID: 8778, 100049587
  • Molecular mass of antigen [kDa]: 51
  • Distribution of antigen: granulocytes, monocytes, dendritic cells, macrophages, B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
Product options: 12

Product information

Size
Order no.
Price

Anti-Siglec-5/Siglec-14-VioBright FITC, human

  • REA393
  • 1:11
  • For research use only
for 30
tests
(1)
130-106-071
-

Anti-Siglec-5/Siglec-14-VioBright FITC, human

  • REA393
  • 1:11
  • For research use only
for 100
tests
(1)
130-106-022
-

Anti-Siglec-5/Siglec-14-PE, human

  • REA393
  • 1:11
  • For research use only
for 30
tests
(1)
130-106-067
-

Anti-Siglec-5/Siglec-14-PE, human

  • REA393
  • 1:11
  • For research use only
for 100
tests
(1)
130-106-018
-

Anti-Siglec-5/Siglec-14-APC, human

  • REA393
  • 1:11
  • For research use only
for 30
tests
(1)
130-106-068
-

Anti-Siglec-5/Siglec-14-APC, human

  • REA393
  • 1:11
  • For research use only
for 100
tests
(1)
130-106-019
-

Anti-Siglec-5/Siglec-14-PE-Vio770, human

  • REA393
  • 1:11
  • For research use only
for 30
tests
(1)
130-106-069
-

Anti-Siglec-5/Siglec-14-PE-Vio770, human

  • REA393
  • 1:11
  • For research use only
for 100
tests
(1)
130-106-020
-

Anti-Siglec-5/Siglec-14-APC-Vio770, human

  • REA393
  • 1:11
  • For research use only
for 30
tests
(1)
130-106-070
-

Anti-Siglec-5/Siglec-14-APC-Vio770, human

  • REA393
  • 1:11
  • For research use only
for 100
tests
(1)
130-106-021
-

Anti-Siglec-5/Siglec-14-Biotin, human

  • REA393
  • 1:11
  • For research use only
for 30
tests
(1)
130-106-170
-

Anti-Siglec-5/Siglec-14-Biotin, human

  • REA393
  • 1:11
  • For research use only
for 100
tests
(1)
130-106-119
-

Related products

2 products available