Anti-Siglec-10 antibodies, human

Anti-Siglec-10 antibodies, human

Clone: REA1048 | Dilution: 1:50
Clone REA1048 recognizes the human siglec-10 antigen, also known as sialic acid-binding Ig-like lectin 10, which is a member of the CD33-related group of siglecs. The cytoplasmic tail of siglec-10 contains four tyrosines, two of which are embedded in ITIM-signaling motifs and are likely to be involved in intracellular signaling. Amongst peripheral blood leucocytes, siglec-10 was found to be expressed on eosinophils, monocytes, and B cells. Higher levels of siglec-10 were found on a minor subset of NK-like cells that express the CD16 low-affinity Fc receptor but lack the CD56 antigen. The molecular properties and expression pattern suggest that siglec-10 may have evolved to function as an inhibitory receptor of the innate immune system.
Additional information: Clone REA1048 displays negligible binding to Fc receptors.

Alternative Names

PRO940, SLG2, Siglec10, Siglec-like protein 2 (SLG2)

Technical specifications

  • Antigen: Siglec-10
  • Clone: REA1048
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: PRO940, SLG2, Siglec10, Siglec-like protein 2 (SLG2)
  • Entrez Gene ID: 89790
  • Molecular mass of antigen [kDa]: 75
  • Distribution of antigen: B cells, monocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615

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