Anti-QA-2 antibodies, mouse

Anti-QA-2 antibodies, mouse

Clone: REA523 | Dilution: 1:10
Clone REA523 recognizes the mouse Qa-2 antigen, a 40 kDa single-pass type I membrane protein, which is also known as H-2 class I histocompatibility antigen Q7 alpha chain (H2-Q7). Qa-2 is a murine non-classical MHC class I molecule involved in the modulation of immune responses by interacting with T CD8
and NK cell inhibitory receptors. The murine Qa-2 genes map to the H-2Q region, between the classical class I H-2D locus and the H-2TL cluster of class lb sequences. This locus encodes a variable number of class Ib genes in different strains. Strains expressing high (Qa-2
), medium (Qa-2
), low (Qa-2
), and no Qa-2 (Qa-2
) were identified. Qa-2 is found as membrane-bound and soluble isoforms generated by alternative splicing. It is expressed mostly by lymphoid-derived cells and plays an important role in controlling growth and murine fetal development and, like HLA-G, the molecule is related to the protection of the fetus by inhibiting maternal NK cell-mediated lysis.
Additional information: Clone REA523 displays negligible binding to Fc receptors.

Alternative Names

H2-Qa2, H2-Q7

Technical specifications

  • Antigen: QA-2
  • Clone: REA523
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: H2-Qa2, H2-Q7
  • Entrez Gene ID: 15018, 110558, 15019
  • Molecular mass of antigen [kDa]: 36
  • Distribution of antigen: B cells, NK cells, T cells, thymocytes, T helper cells, NKT cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio770, APC-Vio770, Biotin
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