Anti-QA-1B antibodies, mouse

Anti-QA-1B antibodies, mouse

Clone: 6A8.6F10.1A6 | Dilution: 1:10
Clone 6A8.6F10.1A6 recognizes murine Qa-1, a 48kDa non-classical MHC class Ib molecule encoded by the H2-T23 gene on chromosome 17. Qa-1 associates with b2-microglobulin and its surface expression is found on activated hematopoietic cells, T cells, DCs, macrophages and neurons. Murine Qa-1 presents a nine amino acid peptide called Qa-1 determinant modifier (Qdm), peptides from proteins associated with infectious or inflammatory response and a heat shock protein 60 (HSP60)-derived peptide (in the absence of Qdm) to immunoregulatory CD8
+
T cells. Qa-1 also serves as a ligand for C-type lectin CD94/NKG2 receptors and depending on the NKG2 family member involved, this interaction can result in an inhibitory or an activating signal.

Alternative Names

H2-T23

Technical specifications

  • Antigen: QA-1B
  • Clone: 6A8.6F10.1A6
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: H2-T23
  • Entrez Gene ID: 15040
  • Molecular mass of antigen [kDa]: 39
  • Distribution of antigen: T cells, hematopoietic stem cells, dendritic cells, macrophages, neurons
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, Biotin
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