Anti-PSMA antibodies, human

Anti-PSMA antibodies, human

Clone: REA408 | Dilution: 1:50
Clone REA408 recognizes the human prostate-specific membrane antigen (PSMA) antigen, a single-pass type II membrane protein which is also known as folate hydrolase 1 (FOLH1), glutamate carboxypeptidase 2 (GCP2), or N-acetylated-alpha-linked acidic dipeptidase I (NAALADase). PSMA is a zinc metallopeptidase which catalyzes the hydrolysis of N-acetylaspartylglutamate to glutamate and N-acetylaspartate. It is expressed with low levels in the small intestine, renal tubular cells, and salivary gland, and is over-expressed in prostate cancer tissue. PSMA is also expressed in the nervous system.
Additional information: Clone REA408 displays negligible binding to Fc receptors.

Alternative Names

FOLH1, FGCP, FOLH, GCP2, GCPII, NAALAD1, PSM, mGCP, NAALADase I

Technical specifications

  • Antigen: PSMA
  • Clone: REA408
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: FOLH1, FGCP, FOLH, GCP2, GCPII, NAALAD1, PSM, mGCP, NAALADase I
  • Entrez Gene ID: 2346
  • Molecular mass of antigen [kDa]: 84
  • Distribution of antigen: small intestine, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, APC, Biotin
  • Selected references

    1. Israeli, R. S. et al. (1993) Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen. Cancer Res. 53(2): 227-230
    2. Ghosh, A. et al. (2004) Tumor target prostate specific membrane antigen (PSMA) and its regulation in prostate cancer. J. Cell. Biochem. 91(3): 528-539
    3. Luthi-Carter, R. et al. (1998) Molecular characterization of human brain N-acetylated alpha-linked acidic dipeptidase (NAALADase). J. Pharmacol. Exp. Ther. 286(2): 1020-1025
Product options: 6
130-118-475

Anti-PSMA-VioBright FITC, human

for 30
tests
(1)
-
130-118-336

Anti-PSMA-VioBright FITC, human

for 100
tests
(1)
-
130-117-790

Anti-PSMA-APC, human

for 30
tests
(1)
-
130-117-678

Anti-PSMA-APC, human

for 100
tests
(1)
-
130-118-012

Anti-PSMA-Biotin, human

for 30
tests
(1)
-
130-117-939

Anti-PSMA-Biotin, human

for 100
tests
(1)
-