Anti-Plexin-D1 antibodies, human

Anti-Plexin-D1 antibodies, human

Clone: REA542 | Dilution: 1:11
Clone REA542 recognizes the human plexin-D1 antigen, a type I transmembrane glycoprotein that is a member of the D subfamily of semaphorin receptors. Plexin-D1 is amongst others the receptor for semaphorin 3E (Sema3E) which is a secreted molecule implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. Plexin-D1 plays an important role in cell-cell signaling and in regulating the migration of a wide spectrum of cell types, and is able to trigger R-Ras inactivation, leading to axonal and cell repulsion
in vitro.
Moreover, it was shown that Sema3E mediates either axonal attraction or repulsion in distinct neuronal populations, depending on the coexpression of neuropilin-1 with plexin-D1. Plexin-D1 expression is generally low in normal adult tissues, it is elevated in endothelial cells of tumor vessels and in cancer cells.
Additional information: Clone REA542 displays negligible binding to Fc receptors.

Alternative Names

PLXND1, PLEXD1

Technical specifications

  • Antigen: Plexin-D1
  • Clone: REA542
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: PLXND1, PLEXD1
  • Entrez Gene ID: 23129
  • Molecular mass of antigen [kDa]: 208
  • Distribution of antigen: endothelial cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, Biotin
  • Selected References

    1. Tamagnone, L. et al. (1999) Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell 99(1): 71-80
    2. Sakurai, A. et al. (2010) Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras. Mol. Cell. Biol. 30(12): 3086-3098
    3. Casazza, A. et al. (2010) Sema3E–Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice. J. Clin. Invest. 120(8): 2684-2698
Product options: 8
130-108-321

Anti-Plexin-D1-VioBright FITC, human

for 30
tests
(1)
-
130-108-298

Anti-Plexin-D1-VioBright FITC, human

for 100
tests
(1)
-
130-108-319

Anti-Plexin-D1-PE, human

for 30
tests
(1)
-
130-108-296

Anti-Plexin-D1-PE, human

for 100
tests
(1)
-
130-108-320

Anti-Plexin-D1-APC, human

for 30
tests
(1)
-
130-108-297

Anti-Plexin-D1-APC, human

for 100
tests
(1)
-
130-108-318

Anti-Plexin-D1-Biotin, human

for 30
tests
(1)
-
130-108-295

Anti-Plexin-D1-Biotin, human

for 100
tests
(1)
-